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Differential Effects of Dexamethasone and Itraconazole on Aspergillus fumigatus-Exacerbated Allergic Airway Inflammation in a Murine Model of Mite-Sensitized Asthma
http://hdl.handle.net/10069/32539
http://hdl.handle.net/10069/32539236a9411-e52b-41e2-8716-81dc9e6fb5f1
名前 / ファイル | ライセンス | アクション |
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Res85_429.pdf (552.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-06-28 | |||||
タイトル | ||||||
タイトル | Differential Effects of Dexamethasone and Itraconazole on Aspergillus fumigatus-Exacerbated Allergic Airway Inflammation in a Murine Model of Mite-Sensitized Asthma | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Allergic bronchopulmonary aspergillosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Aspergillus fumigates | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bronchial asthma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dermatophagoides farinae | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Itraconazole | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Phagocytosis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Matsuse, Hiroto
× Matsuse, Hiroto× Fukushima, Chizu× Fukahori, Susumu× Tsuchida, Tomoko× Kawano, Tetsuya× Nishino, Tomoya× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Fungal exposure is associated with particularly severe asthma. Nevertheless, the effects of anti-fungal treatments on fungus-exacerbated asthma need to be determined. Objectives: The present study aimed to compare the effects of itraconazole (ITCZ) and dexamethasone (Dex) on Aspergillus fumigatus (Af)-exacerbated preexisting Dermatophagoides farinae (Df) allergen-sensitized allergic airway inflammation. Methods: Four groups of BALB/c mice were prepared: control, Df-sensitized plus Af-infected mice (Df-Af), and Df-Af mice treated with Dex (Df-Af-Dex) or with ITCZ (Df-Af-ITCZ). Pulmonary pathology and cytokine profiles in the airway were evaluated. In a different set of experiments, the effects of Dex on alveolar macrophage (AM) phagocytosis of Af conidia were determined in Df-sensitized mice. Results:Af infection significantly increased the level of eosinophils and neutrophils in the airway of Df-sensitized mice. While Dex significantly decreased eosinophils, ITCZ significantly decreased both eosinophils and neutrophils in Df-Af mice. Dex significantly decreased IL-5, whereas ITCZ significantly reduced MIP-2 in the airway. Compared to controls, AM isolated from Df-sensitized mice had significantly reduced phagocytotic activity of Af conidia. However, Dex significantly improved phagocytotic activity of AM in Df-sensitized mice. Conclusions: The present study showed that Dex and ITCZ differently regulated Af-exacerbated allergic airway inflammation; the former inhibits eosinophilic inflammation and the latter inhibits neutrophilic as well as eosinophilic inflammation by regulating different cytokines. Additionally, Dex enhanced the phagocytotic activity of AM in allergic asthma. Thus, a combination of Dex and ITCZ might be effective for the management of fungus-exacerbated asthma. | |||||
書誌情報 |
Respiration 巻 85, 号 5, p. 429-435, 発行日 2013-04 |
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出版者 | ||||||
出版者 | S. Karger AG | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00257931 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14230356 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1159/000345861 | |||||
権利 | ||||||
権利情報 | © 2013 S. Karger AG, Basel. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Respiration, 85(5), pp.429-435; 2013 |