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Involvement of Leptin in the Progression of Experimentally Induced Peritoneal Fibrosis in Mice
http://hdl.handle.net/10069/32684
http://hdl.handle.net/10069/32684627aea22-8d0e-49dd-971c-3f8492406d2b
名前 / ファイル | ライセンス | アクション |
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AHC46_75.pdf (1.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-07-09 | |||||
タイトル | ||||||
タイトル | Involvement of Leptin in the Progression of Experimentally Induced Peritoneal Fibrosis in Mice | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Angiogenesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Leptin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Macrophage infiltration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Peritoneal dialysis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Peritoneal fibrosis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nakazawa, Masayuki
× Nakazawa, Masayuki× Obata, Yoko× Nishino, Tomoya× Abe, Shinichi× Nakazawa, Yuka× Abe, Katsushige× Furusu, Akira× Miyazaki, Masanobu× Koji, Takehiko× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 013LeptinThe isJapana hormoneSociety mainlyof Histochemistryproduced byandwhite adipose cells, and regulates body fat and food intake by acting on hypothalamus. Leptin receptor is expressed not only in the hypothalamus but in a variety of peripheral tissues, suggesting that leptin has pleiotropic functions. In this study, we investigated the effect of leptin on the progression of peritoneal fibrosis induced by intraperitoneal injection of chlorhexidine gluconate (CG) every other day for 2 or 3 weeks in mice. This study was conducted in male C57BL/6 mice and leptin-deficient ob/ob mice. Peritoneal fluid, blood, and peritoneal tissues were collected 15 or 22 days after CG injection. CG injection increased the level of leptin in serum and peritoneal fluid with thickening of submesothelial compact zone in wild type mice, but CG-injected ob/ob mice attenuate peritoneal fibrosis, and markedly reduced the number of myofibroblasts, infiltrating macrophages, and blood vessels in the thickened submesothelial area. The 2-week leptin administration induced a more thickened peritoneum in the CG-injected C57BL/6 mice than in the PBS group. Our results indicate that an upregulation of leptin appears to play a role in fibrosis and inflammation during peritoneal injury, and reducing leptin may be a therapeutically potential for peritoneal fibrosis. | |||||
書誌情報 |
ACTA HISTOCHEMICA ET CYTOCHEMICA 巻 46, 号 2, p. 75-84, 発行日 2013-04-30 |
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出版者 | ||||||
出版者 | 日本組織細胞化学会 | |||||
出版者別言語 | ||||||
Japan Society of Histochemistry and Cytochemistry | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00445991 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13475800 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1267/ahc.13005 | |||||
権利 | ||||||
権利情報 | © 2013 The Japan Society of Histochemistry and Cytochemistry | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://hdl.handle.net/10069/34625 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | ACTA HISTOCHEMICA ET CYTOCHEMICA, 46(2), pp,75-84; 2013 |