WEKO3
アイテム
{"_buckets": {"deposit": "f8a44912-a15a-48de-ae4e-dafa40549057"}, "_deposit": {"created_by": 2, "id": "7937", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "7937"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00007937", "sets": ["74"]}, "author_link": ["32737", "32733", "32736", "32734", "32735"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2013-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "483", "bibliographicPageStart": "479", "bibliographicVolumeNumber": "5", "bibliographic_titles": [{"bibliographic_title": "Metallomics"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Selenium-containing proteins (e.g., glutathione peroxidases) are important antioxidants in neuronal defense against oxidative stress. In this study, the production of amyloid-β (Aβ) plaques in the brain of the Tg2576 transgenic mice was investigated under dietary selenium-deficient conditions. The 16-week-old mice were fed a selenium-deficient diet (0.004 μg-selenium g-1-diet) or a selenium-adequate diet (0.386 μg-selenium g -1 diet) for 76 weeks. The selenium concentrations of the organs/tissues in the selenium-deficient diet-fed mice were significantly decreased in comparison to those in the selenium-adequate diet-fed mice; 1.7% of that in the selenium-adequate diet-fed mice in the liver and 43% of that in the selenium-adequate diet-fed mice in the brain. The Aβ plaques formed in the brain were fluorescently stained with thioflavin T, and then the obtained images of the brain slices were qualitatively analyzed. The feeding of the selenium-deficient diet to the Tg2576 transgenic mice resulted in more than a two-fold increase in the total area of the Aβ plaques in comparison to that of the selenium-adequate diet. The elevated Aβ plaque deposition in the selenium-deficient mice can be explained as a consequence of decrease in the selenium concentration, which suggests that the selenium status is associated with the production and/or the clearance of the Aβ peptide. The selenium-deficiency could possibly promote the onset and/or progression of Alzheimer\u0027s disease (AD) dementia, if the Aβ peptides initiate a sequence of events that lead to AD dementia. Consequently, the results shown here suggest that AD has an important relation with the selenium status in vivo.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Metallomics, 5(5), pp.479-483; 2013", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Royal Society of Chemistry"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1039/c3mt00035d", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2013 The Royal Society of Chemistry."}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "17565901", "subitem_source_identifier_type": "ISSN"}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1756591X", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Haratake, Mamoru"}], "nameIdentifiers": [{"nameIdentifier": "32733", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshida, Sakura"}], "nameIdentifiers": [{"nameIdentifier": "32734", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mandai, Megumi"}], "nameIdentifiers": [{"nameIdentifier": "32735", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fuchigami, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "32736", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakayama, Morio"}], "nameIdentifiers": [{"nameIdentifier": "32737", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-21"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Metal5_479.pdf", "filesize": [{"value": "417.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 417000.0, "url": {"label": "Metal5_479.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/7937/files/Metal5_479.pdf"}, "version_id": "e1734473-2591-4983-9ce8-2168ccdec4a3"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Elevated amyloid-β plaque deposition in dietary selenium-deficient Tg2576 transgenic mice", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Elevated amyloid-β plaque deposition in dietary selenium-deficient Tg2576 transgenic mice"}]}, "item_type_id": "2", "owner": "2", "path": ["74"], "permalink_uri": "http://hdl.handle.net/10069/32832", "pubdate": {"attribute_name": "公開日", "attribute_value": "2014-06-01"}, "publish_date": "2014-06-01", "publish_status": "0", "recid": "7937", "relation": {}, "relation_version_is_last": true, "title": ["Elevated amyloid-β plaque deposition in dietary selenium-deficient Tg2576 transgenic mice"], "weko_shared_id": -1}
Elevated amyloid-β plaque deposition in dietary selenium-deficient Tg2576 transgenic mice
http://hdl.handle.net/10069/32832
http://hdl.handle.net/10069/32832a9c7e33a-7189-40b8-b9f1-c5334d83d52c
名前 / ファイル | ライセンス | アクション |
---|---|---|
Metal5_479.pdf (417.0 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2014-06-01 | |||||
タイトル | ||||||
タイトル | Elevated amyloid-β plaque deposition in dietary selenium-deficient Tg2576 transgenic mice | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Haratake, Mamoru
× Haratake, Mamoru× Yoshida, Sakura× Mandai, Megumi× Fuchigami, Takeshi× Nakayama, Morio |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Selenium-containing proteins (e.g., glutathione peroxidases) are important antioxidants in neuronal defense against oxidative stress. In this study, the production of amyloid-β (Aβ) plaques in the brain of the Tg2576 transgenic mice was investigated under dietary selenium-deficient conditions. The 16-week-old mice were fed a selenium-deficient diet (0.004 μg-selenium g-1-diet) or a selenium-adequate diet (0.386 μg-selenium g -1 diet) for 76 weeks. The selenium concentrations of the organs/tissues in the selenium-deficient diet-fed mice were significantly decreased in comparison to those in the selenium-adequate diet-fed mice; 1.7% of that in the selenium-adequate diet-fed mice in the liver and 43% of that in the selenium-adequate diet-fed mice in the brain. The Aβ plaques formed in the brain were fluorescently stained with thioflavin T, and then the obtained images of the brain slices were qualitatively analyzed. The feeding of the selenium-deficient diet to the Tg2576 transgenic mice resulted in more than a two-fold increase in the total area of the Aβ plaques in comparison to that of the selenium-adequate diet. The elevated Aβ plaque deposition in the selenium-deficient mice can be explained as a consequence of decrease in the selenium concentration, which suggests that the selenium status is associated with the production and/or the clearance of the Aβ peptide. The selenium-deficiency could possibly promote the onset and/or progression of Alzheimer's disease (AD) dementia, if the Aβ peptides initiate a sequence of events that lead to AD dementia. Consequently, the results shown here suggest that AD has an important relation with the selenium status in vivo. | |||||
書誌情報 |
Metallomics 巻 5, 号 5, p. 479-483, 発行日 2013-05 |
|||||
出版者 | ||||||
出版者 | Royal Society of Chemistry | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 17565901 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1756591X | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1039/c3mt00035d | |||||
権利 | ||||||
権利情報 | © 2013 The Royal Society of Chemistry. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Metallomics, 5(5), pp.479-483; 2013 |