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Relationship between Microvessel Count and Clinicopathological Characteristics and Postoperative Survival in Patients with Pancreatic Carcinoma
http://hdl.handle.net/10069/30982
http://hdl.handle.net/10069/309828f843b1f-c6c2-445a-8295-5053e5d9cea7
名前 / ファイル | ライセンス | アクション |
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HepGas59_1964.pdf (1.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-10-01 | |||||
タイトル | ||||||
タイトル | Relationship between Microvessel Count and Clinicopathological Characteristics and Postoperative Survival in Patients with Pancreatic Carcinoma | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD34 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Microvessel count | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pancreatic carcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pancreatic resection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Survival | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nanashima, Atsushi
× Nanashima, Atsushi× Shibata, Kenichirou× Nakayama, Toshiyuki× Abo, Takafumi× Nonaka, Takashi× Fukuda, Daisuke× Fukuoka, Hidetoshi× Hidaka, Shigekazu× Takeshita, Hiroaki× Sawai, Terumitsu× Yasutake, Toru× Nagayasu, Takeshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background/Aims: The present study aimed to elucidate the relationship between microvessel count (MVC) according to CD34 expression and clinicopathological characteristics or prognosis in pancreatic carcinoma (PC) patients who underwent hepatectomy. Methodology: CD34 expression was analyzed using immunohistochemical methods. Mean MVC in 5 areas per specimen and clinicopathological factors were consecutively examined in 42 PC patients. Results: Median MVC for PC patients was 123/mm2, which was applied as a cut-off value. Higher MVC was significantly associated with the advanced Japanese tumor-node-metastasis stage IVa and IVb (p=0.034). Univariate survival analysis identified higher carcinoembryonic antigen (CEA) and CA19-9 level, infiltrative type on macroscopic examination, invasive ductal carcinoma, node metastasis and higher tumor-node-metastasis classification were significantly associated with poor survival. The 5-year overall survival rate in the higher MVC group tended to be lower than that in the higher MVC group (37 vs. 55%), but not statistically significant (p=0.15). Conclusions: Tumor MVC might be a candidate prognostic marker of PC patient survival after pancreatectomy and further investigation in a larger series is warranted to clarify the significance of this marker. | |||||
書誌情報 |
Hepato-gastroenterology 巻 59, 号 118, p. 1964-1969, 発行日 2012-09 |
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出版者 | ||||||
出版者 | H.G.E. Update Medical Publishing Ltd. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01726390 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 22819916 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.5754/hge10618 | |||||
権利 | ||||||
権利情報 | © H.G.E. Update Medical Publishing S.A. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Hepato-gastroenterology, 59(118), pp.1964-1969; 2012 |