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HCV infection is associated with lipid disorders because this virus utilizes the host lipid metabolism to sustain its life cycle. Several studies have indicated that higher concentrations of serum cholesterol and LDL before treatment are important predictors of higher rates of sustained virological response (SVR). However, most of these studies involved patients infected with HCV genotype 1. Thus, we performed a multi-institutional clinical study to evaluate the impact of lipid profiles on SVR rates in patients with HCV genotype 2. Methods. A total of 100 chronic hepatitis C patients with HCV genotype 2 who received peg-IFN alfa-2b and ribavirin therapy were consecutively enrolled. The significance of age, sex, BMI, AST level, ALT level, WBC, hemoglobin, platelet count, gamma-glutamyltransferase, total cholesterol level (TC), LDL level, HCV RNA, and histological evaluation was examined for SVR using logistic regression analysis. Results. 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Baseline Serum Cholesterol Is Associated with a Response to Pegylated Interferon Alfa-2b and Ribavirin Therapy for Chronic Hepatitis C Genotype 2
http://hdl.handle.net/10069/31110
http://hdl.handle.net/10069/311107bf4f600-f63e-444f-ba50-20004ad9166c
名前 / ファイル | ライセンス | アクション |
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GRP2012_317580.pdf (556.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-03-27 | |||||
タイトル | ||||||
タイトル | Baseline Serum Cholesterol Is Associated with a Response to Pegylated Interferon Alfa-2b and Ribavirin Therapy for Chronic Hepatitis C Genotype 2 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | alanine aminotransferase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | aspartate aminotransferase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cholesterol | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gamma glutamyltransferase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | low density lipoprotein cholesterol | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | peginterferon alpha2b plus ribavirin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | virus RNA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | adult | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | age distribution | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | alanine aminotransferase blood level | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | article | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | aspartate aminotransferase blood level | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | blood sampling | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | body mass | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cholesterol blood level | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | clinical study | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | female | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gamma glutamyl transferase blood level | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | genotype | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hepatitis C | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hepatitis C virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | histology | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | human | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | leukocyte count | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | major clinical study | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | male | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | multicenter study | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | retrospective study | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | risk factor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thrombocyte count | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | treatment response | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | viremia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | virus load | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Taura, Naota
× Taura, Naota× Ichikawa, Tatsuki× Miyaaki, Hisamitsu× Kadokawa, Yoshiko× Tsutsumi, Takuya× Tsuruta, Shotaro× Kato, Yuji× Inoue, Osami× Kinoshita, Noboru× Ohba, Kazuo× Kato, Hiroyuki× Ohata, Kazuyuki× Masuda, Junichi× Hamasaki, Keisuke× Yatsuhashi, Hiroshi× Nakao, Kazuhiko |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background. HCV infection is associated with lipid disorders because this virus utilizes the host lipid metabolism to sustain its life cycle. Several studies have indicated that higher concentrations of serum cholesterol and LDL before treatment are important predictors of higher rates of sustained virological response (SVR). However, most of these studies involved patients infected with HCV genotype 1. Thus, we performed a multi-institutional clinical study to evaluate the impact of lipid profiles on SVR rates in patients with HCV genotype 2. Methods. A total of 100 chronic hepatitis C patients with HCV genotype 2 who received peg-IFN alfa-2b and ribavirin therapy were consecutively enrolled. The significance of age, sex, BMI, AST level, ALT level, WBC, hemoglobin, platelet count, gamma-glutamyltransferase, total cholesterol level (TC), LDL level, HCV RNA, and histological evaluation was examined for SVR using logistic regression analysis. Results. The 100 patients infected with HCV genotype 2 were divided into 2 groups, an SVR group and a non-SVR group. Characteristics of each group were subsequently compared. There was no significant difference in the level of HCV RNA, BMI, platelet, TG, or stage of fibrosis between the groups. However, there were significant differences in the levels of TC and LDL-C. In multivariate logistic regression analysis using baseline characteristics, high TC level was an independent and significant risk factor (relative risk 18.59, P = 0.015) for SVR. Conclusion. Baseline serum total cholesterol levels should be considered when assessing the likelihood of sustained treatment response following the course of peg-IFN and ribavirin therapy in patients with chronic HCV genotype 2 infection. | |||||
書誌情報 |
Gastroenterology Research and Practice 巻 2012, p. 1-7, 発行日 2012 |
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出版者 | ||||||
出版者 | Hindawi Publishing Corporation | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 16876121 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1687630X | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1155/2012/317580 | |||||
権利 | ||||||
権利情報 | © 2012 Naota Taura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Gastroenterology Research and Practice, 2012, 317580; 2012 |