WEKO3
アイテム
{"_buckets": {"deposit": "399a5e28-5766-4087-83cb-f008bf85e658"}, "_deposit": {"created_by": 2, "id": "8359", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "8359"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00008359", "sets": ["30"]}, "author_link": ["34082", "34084", "34083"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "446", "bibliographicPageStart": "443", "bibliographicVolumeNumber": "6", "bibliographic_titles": [{"bibliographic_title": "Prion"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Despite recent progress in the understanding of prion diseases, little is known about the host-defense mechanisms against prion. Although it has long been thought that type I interferon (IFN-I) has no protective effect on prion infection, certain key molecules in innate immunity such as toll-like receptor (TLR) 4 seemed to be involved in the host response. For this reason we decided to focus on TLRs and investigate the role of a transcription factor, interferon regulatory factor 3 (IRF3), because the absence of MyD88, a major adaptor signaling molecule of TLRs, has no effect on the survival of prion infected mice. Intriguingly, survival periods of prion inoculated IRF3-knockout mice became significantly shorter than those of wildtype mice. In addition, IRF3 stimulation inhibited PrPSc replication in prion persistently- infected cells, and a de novo prion infection assay revealed that IRF3-overexpression could make host cells resistant to prion infection. Our work suggests that IRF3 may play a key role in innate immune responses against invasion of prion pathogens. Activated IRF3 could upregulate several anti-pathogen factors, including IFN-I, and induce sequential responses. Although the mechanism for the anti-prion effects mediated by IRF3 has yet to be clarified, certain interferon responsive genes might be involved in the anti-prion host-defense mechanism.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Prion, 6(5), pp.443-446; 2012", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Landes Bioscience"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.4161/pri.22579", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2012 Landes Bioscience."}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "19336896", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ishibashi, Daisuke"}], "nameIdentifiers": [{"nameIdentifier": "34082", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Atarashi, Ryuichiro"}], "nameIdentifiers": [{"nameIdentifier": "34083", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishida, Noriyuki"}], "nameIdentifiers": [{"nameIdentifier": "34084", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-21"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Prion6_443.pdf", "filesize": [{"value": "310.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 310700.0, "url": {"label": "Prion6_443.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/8359/files/Prion6_443.pdf"}, "version_id": "6d8e7ada-e356-48b1-aabc-4f9972f9beb2"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Host defense", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Innate immunity", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Interferon regulatory factor 3 (IRF3)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Prion", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Type I interferon (IFN)", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Protective role of MyD88-independent innate immune responses against prion infection", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Protective role of MyD88-independent innate immune responses against prion infection"}]}, "item_type_id": "2", "owner": "2", "path": ["30"], "permalink_uri": "http://hdl.handle.net/10069/31113", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-12-01"}, "publish_date": "2013-12-01", "publish_status": "0", "recid": "8359", "relation": {}, "relation_version_is_last": true, "title": ["Protective role of MyD88-independent innate immune responses against prion infection"], "weko_shared_id": -1}
Protective role of MyD88-independent innate immune responses against prion infection
http://hdl.handle.net/10069/31113
http://hdl.handle.net/10069/31113d98dc27d-3d18-474e-a302-53379cf6d641
名前 / ファイル | ライセンス | アクション |
---|---|---|
Prion6_443.pdf (310.7 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2013-12-01 | |||||
タイトル | ||||||
タイトル | Protective role of MyD88-independent innate immune responses against prion infection | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Host defense | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Innate immunity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Interferon regulatory factor 3 (IRF3) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Prion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Type I interferon (IFN) | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ishibashi, Daisuke
× Ishibashi, Daisuke× Atarashi, Ryuichiro× Nishida, Noriyuki |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Despite recent progress in the understanding of prion diseases, little is known about the host-defense mechanisms against prion. Although it has long been thought that type I interferon (IFN-I) has no protective effect on prion infection, certain key molecules in innate immunity such as toll-like receptor (TLR) 4 seemed to be involved in the host response. For this reason we decided to focus on TLRs and investigate the role of a transcription factor, interferon regulatory factor 3 (IRF3), because the absence of MyD88, a major adaptor signaling molecule of TLRs, has no effect on the survival of prion infected mice. Intriguingly, survival periods of prion inoculated IRF3-knockout mice became significantly shorter than those of wildtype mice. In addition, IRF3 stimulation inhibited PrPSc replication in prion persistently- infected cells, and a de novo prion infection assay revealed that IRF3-overexpression could make host cells resistant to prion infection. Our work suggests that IRF3 may play a key role in innate immune responses against invasion of prion pathogens. Activated IRF3 could upregulate several anti-pathogen factors, including IFN-I, and induce sequential responses. Although the mechanism for the anti-prion effects mediated by IRF3 has yet to be clarified, certain interferon responsive genes might be involved in the anti-prion host-defense mechanism. | |||||
書誌情報 |
Prion 巻 6, 号 5, p. 443-446, 発行日 2012-11 |
|||||
出版者 | ||||||
出版者 | Landes Bioscience | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19336896 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.4161/pri.22579 | |||||
権利 | ||||||
権利情報 | © 2012 Landes Bioscience. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Prion, 6(5), pp.443-446; 2012 |