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NPY Deficiency Prevents Postmenopausal Adiposity by Augmenting Estradiol-Mediated Browning
http://hdl.handle.net/10069/40028
http://hdl.handle.net/10069/40028da9e7e84-28db-42cc-969e-15564dfd4640
名前 / ファイル | ライセンス | アクション |
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JGSA75_1042.pdf (2.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-06-10 | |||||
タイトル | ||||||
タイトル | NPY Deficiency Prevents Postmenopausal Adiposity by Augmenting Estradiol-Mediated Browning | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adipose tissue | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fat metabolism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Estrogen | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Park, Seongjoon
× Park, Seongjoon× Nayantai, Erkhembayar× Komatsu, Toshimitsu× Hayashi, Hiroko× Mori, Ryoichi× Shimokawa, Isao |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The orexigenic hormone neuropeptide Y (NPY) plays a pivotal role in the peripheral regulation of fat metabolism. However, the mechanisms underlying the effects of sex on NPY function have not been extensively analyzed. In this study, we examined the effects of NPY deficiency on fat metabolism in male and female mice. Body weight was slightly decreased, whereas white adipose tissue (WAT) mass was significantly decreased as the thermogenic program was upregulated in NPY-/- female mice compared with that in wild-type mice; these factors were not altered in response to NPY deficiency in male mice. Moreover, lack of NPY resulted in an increase in luteinizing hormone (LH) expression in the pituitary gland, with concomitant activation of the estradiol-mediated thermogenic program in inguinal WAT, and alleviated age-related modification of adiposity in female mice. Taken together, these data revealed a novel intracellular mechanism of NPY in the regulation of fat metabolism and highlighted the sexual dimorphism of NPY as a promising target for drug development to reduce postmenopausal adiposity. | |||||
書誌情報 |
The Journals of Gerontology: Series A 巻 75, 号 6, p. 1042-1049, 発行日 2019-01-29 |
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出版者 | ||||||
出版者 | Oxford University Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10795006 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1758535X | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/gerona/gly282 | |||||
権利 | ||||||
権利情報 | c The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals. permissions@oup.com | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The journals of gerontology, Series A, 75(6), pp.1042-1049; 2020 |