WEKO3
アイテム
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Each prescription was given orally to rats for 10 weeks after the excision of five-sixths of their kidney volumes, and its effect was compared with non-nephrectomized and normal rats. Rats given Hachimi-jio-gan and Bakumi-jio-gan showed an improvement of renal functional parameters such as serum urea nitrogen, creatinine, creatinine clearance, and urinary protein. The nephrectomized rats exhibited the up-regulation of nicotinamide adenine dinucleotide phosphate oxidase subunits, c-Jun N-terminal kinase (JNK), phosphor-JNK, c-Jun, transforming growth factor-β nuclear factor-kappa B, cyclooxygenase-2, inducible nitric oxide synthase, monocyte chemotactic protein-1, intracellular adhesion molecule-1, Bax, cytochrome c, and caspase-3, and down-regulation of NF-E2-related factor 2, heme oxygenase-1, and survivin; however, Bakumi-jio-gan administration acts as a regulator in inflammatory reactions caused by oxidative stress in renal failure. 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Rokumi-jio-gan-Containing Prescriptions Attenuate Oxidative Stress, Inflammation, and Apoptosis in the Remnant Kidney
http://hdl.handle.net/10069/31215
http://hdl.handle.net/10069/3121567ea9d60-d6b5-4e54-868b-07bbac96830e
名前 / ファイル | ライセンス | アクション |
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ECAM2012_587902.pdf (3.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-04-05 | |||||
タイトル | ||||||
タイトル | Rokumi-jio-gan-Containing Prescriptions Attenuate Oxidative Stress, Inflammation, and Apoptosis in the Remnant Kidney | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bakumijiogan | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | caspase 3 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | creatinine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cyclooxygenase 2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cytochrome c | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hachimijiogan | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | heme oxygenase 1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | immunoglobulin enhancer binding protein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | inducible nitric oxide synthase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | intercellular adhesion molecule 1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | monocyte chemotactic protein 1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | plant medicinal product | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | protein Bax | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | protein c jun | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | reduced nicotinamide adenine dinucleotide phosphate oxidase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | reduced nicotinamide adenine dinucleotide phosphate oxidase 4 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | stress activated protein kinase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | survivin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | transcription factor NF E2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | transcription factor Nrf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | transforming growth factor beta1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | unclassified drug | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | animal experiment | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | animal model | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | animal tissue | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | apoptosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | arteriolosclerosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | article | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | controlled study | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | creatinine clearance | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | down regulation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | fluid intake | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | food intake | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glomerulosclerosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | histopathology | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | inflammation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | interstitial nephritis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | kidney failure | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | kidney function | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | kidney parenchyma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | male | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nephrectomy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nonhuman | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | oxidative stress | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | prescription | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | priority journal | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | protein expression | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | protein urine level | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rat | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | upregulation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | urea nitrogen blood level | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | weight change | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Park, Chan Hum
× Park, Chan Hum× Lee, Sul Lim× Okamoto, Takuya× Tanaka, Takashi× Yokozawa, Takako |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Two Rokumi-jio-gan-containing prescriptions (Hachimi-jio-gan and Bakumi-jio-gan) were selected to examine their actions in nephrectomized rats. Each prescription was given orally to rats for 10 weeks after the excision of five-sixths of their kidney volumes, and its effect was compared with non-nephrectomized and normal rats. Rats given Hachimi-jio-gan and Bakumi-jio-gan showed an improvement of renal functional parameters such as serum urea nitrogen, creatinine, creatinine clearance, and urinary protein. The nephrectomized rats exhibited the up-regulation of nicotinamide adenine dinucleotide phosphate oxidase subunits, c-Jun N-terminal kinase (JNK), phosphor-JNK, c-Jun, transforming growth factor-β nuclear factor-kappa B, cyclooxygenase-2, inducible nitric oxide synthase, monocyte chemotactic protein-1, intracellular adhesion molecule-1, Bax, cytochrome c, and caspase-3, and down-regulation of NF-E2-related factor 2, heme oxygenase-1, and survivin; however, Bakumi-jio-gan administration acts as a regulator in inflammatory reactions caused by oxidative stress in renal failure. Moreover, the JNK pathway and apoptosis-related protein expressions, Bax, caspase-3, and survivin, were ameliorated to the normal levels by Hachimi-jio-gan administration. The development of renal lesions, glomerular sclerosis, tubulointerstitial damage, and arteriolar sclerotic lesions, estimated by histopathological evaluation and scoring, was strong in the groups administered Hachimi-jio-gan rather than Bakumi-jio-gan. This study suggests that Rokumi-jio-gan-containing prescriptions play a protective role in the progression of renal failure. | |||||
書誌情報 |
Evidence-Based Complementary and Alternative Medicine 巻 2012, p. 1-15, 発行日 2012 |
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出版者 | ||||||
出版者 | Hindawi Publishing Corporation | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1741427X | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 17414288 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1155/2012/587902 | |||||
権利 | ||||||
権利情報 | © 2012 Chan Hum Park et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Evidence-Based Complementary and Alternative Medicine, 2012, 587902; 2012 |