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Algicidal hydroxylated C18 unsaturated fatty acids from the red alga Tricleocarpa jejuensis: Identification, synthesis and biological activity
http://hdl.handle.net/10069/40036
http://hdl.handle.net/10069/400365cdd43ff-00f6-44eb-95db-d43c4a42b3da
名前 / ファイル | ライセンス | アクション |
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Fitoterapia 145_104639.pdf (1.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-06-15 | |||||
タイトル | ||||||
タイトル | Algicidal hydroxylated C18 unsaturated fatty acids from the red alga Tricleocarpa jejuensis: Identification, synthesis and biological activity | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Anti-microalgal activity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chattonella antiqua | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hydroxylated trans-unsaturated fatty acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | OxylipinTricleocarpa jejuensis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Zha, Shijiao
× Zha, Shijiao× Kuwano, Kazuyoshi× Shibahara, Tomohiro× Ishibashi, Fumito |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Bioassay-guided separation of a methanol extract of Tricleocarpa jejuensis by monitoring algicidal activity against the red tide phytoplankton Chattonella antiqua led to the isolation of an active fraction consisting of a mixture of four isomeric compounds. The active compounds were identified as (E)-9-hydroxyoctadec-10-enoic acid (1), (E)-10-hydroxyoctadec-8-enoic acid (2), (E)-11-hydroxyoctadec-12-enoic acid (3) and (E)-12-hydroxyoctadec-10-enoic acid (4) by NMR, IR and mass spectral data. The structures were confirmed by comparison of the NMR and MS data with those of authentic samples of 1?4 obtained by unambiguous syntheses. Synthesized hydroxy acids 1?4 and related compounds were assessed for algicidal activity against C. antiqua and it was found that all of 1?4 had high activity (>80% mortality at 24 h) at a concentration of 20 μg/mL. A structure?activity relationship study using 11 related compounds revealed that the presence of the hydroxyl group is important for the activity and the double bond may be replaced with a triple bond. | |||||
書誌情報 |
Fitoterapia 巻 145, p. 104639, 発行日 2020-05-28 |
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出版者 | ||||||
出版者 | Elsevier B.V. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0367326X | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.fitote.2020.104639 | |||||
権利 | ||||||
権利情報 | c 2020 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Fitoterapia, 145, art.no.104639; 2020 |