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Gene regulatory landscape in osteoblast differentiation
http://hdl.handle.net/10069/40037
http://hdl.handle.net/10069/4003771fa7b2a-3cdb-4ce8-9bf6-750d1483e812
名前 / ファイル | ライセンス | アクション |
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Bone137_115458.pdf (280.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-12-18 | |||||
タイトル | ||||||
タイトル | Gene regulatory landscape in osteoblast differentiation | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Epigenetics | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Epigenome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gene regulatory landscape | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gene regulatory networks | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Osteoblasts | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Transcriptional regulators | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hojo, Hironori
× Hojo, Hironori× Ohba, Shinsuke |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The development of osteoblasts, a bone-forming cell population, occurs in conjunction with development of the skeleton, which creates our physical framework and shapes the body. In the past two decades, genetic studies have uncovered the molecular framework of this process?namely, transcriptional regulators and signaling pathways coordinate the cell fate determination and differentiation of osteoblasts in a spatial and temporal manner. Recently emerging genome-wide studies provide additional layers of understanding of the gene regulatory landscape during osteoblast differentiation, allowing us to gain novel insight into the modes of action of the key regulators, functional interaction among the regulator-bound enhancers, epigenetic regulations, and the complex nature of regulatory inputs. In this review, we summarize current understanding of the transcriptional regulation in osteoblasts, in terms of the gene regulatory landscape. | |||||
書誌情報 |
Bone 巻 137, p. 115458, 発行日 2020-05-28 |
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出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 87563282 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.bone.2020.115458 | |||||
権利 | ||||||
権利情報 | c 2020 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Bone, 137, art.no.115458; 2020 |