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We assessed the effect of milrinone application timing after reperfusion against myocardial stunning as compared with levosimendan in swine. Furthermore, we examined the role of p38 mitogen-activated protein kinase (p38 MAPK) in the milrinone-induced cardioprotection. Design. All swine were subjected to 12-minutes ischemia followed by 90-minutes reperfusion to generate stunned myocardium. Milrinone or levosimendan was administered intravenously either for 20 minutes starting just after reperfusion or for 70 minutes starting 20 minutes after reperfusion. In another group, SB203580, a selective p38 MAPK inhibitor, was administered with and without milrinone. Regional myocardial contractility was assessed by percent segment shortening (%SS). Results. Milrinone starting just after reperfusion, but not starting 20 minutes after reperfusion, improved %SS at 30, 60, and 90 minutes after reperfusion compared with that in the control group. 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Milrinone and levosimendan administered after reperfusion improve myocardial stunning in swine
http://hdl.handle.net/10069/31301
http://hdl.handle.net/10069/313011432cb5d-2878-482d-97ac-b5ac6334ff91
名前 / ファイル | ライセンス | アクション |
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SCJ47_50.pdf (862.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-03-01 | |||||
タイトル | ||||||
タイトル | Milrinone and levosimendan administered after reperfusion improve myocardial stunning in swine | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ischemia reperfusion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Levosimendan | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Milrinone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Myocardial stunning | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | P38 mitogen-activated protein kinase | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Shibata, Itsuko
× Shibata, Itsuko× Cho, Sungsam× Yoshitomi, Osamu× Ureshino, Hiroyuki× Maekawa, Takuji× Hara, Tetsuya× Sumikawa, Koji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objectives. We assessed the effect of milrinone application timing after reperfusion against myocardial stunning as compared with levosimendan in swine. Furthermore, we examined the role of p38 mitogen-activated protein kinase (p38 MAPK) in the milrinone-induced cardioprotection. Design. All swine were subjected to 12-minutes ischemia followed by 90-minutes reperfusion to generate stunned myocardium. Milrinone or levosimendan was administered intravenously either for 20 minutes starting just after reperfusion or for 70 minutes starting 20 minutes after reperfusion. In another group, SB203580, a selective p38 MAPK inhibitor, was administered with and without milrinone. Regional myocardial contractility was assessed by percent segment shortening (%SS). Results. Milrinone starting just after reperfusion, but not starting 20 minutes after reperfusion, improved %SS at 30, 60, and 90 minutes after reperfusion compared with that in the control group. SB203580 abolished the beneficial effect of milrinone. On the other hand, levosimendan starting 20 minutes after reperfusion, but not for 20 minutes starting just after reperfusion, improved %SS at 60 and 90 minutes after reperfusion. Conclusions. Milrinone should be administered just after reperfusion to protect myocardial stunning through p38 MAPK, whereas levosimendan improvement of contractile function could be mainly dependent on its positive inotropic effect. | |||||
書誌情報 |
Scandinavian Cardiovascular Journal 巻 47, 号 1, p. 50-57, 発行日 2013-02 |
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出版者 | ||||||
出版者 | Informa Healthcare | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14017431 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 16512006 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3109/14017431.2012.732236 | |||||
権利 | ||||||
権利情報 | © 2013 Informa Healthcare. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Scandinavian Cardiovascular Journal, 47(1), pp.50-57; 2013 |