WEKO3
アイテム
{"_buckets": {"deposit": "db8a8660-f01b-4964-8bac-06be93e1a6b2"}, "_deposit": {"created_by": 2, "id": "867", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "867"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00000867", "sets": ["11"]}, "author_link": ["4112", "4115", "4113", "4114", "4111"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-05-29", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageStart": "3892", "bibliographicVolumeNumber": "21", "bibliographic_titles": [{"bibliographic_title": "International Journal of Molecular Sciences"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "BACKGROUND: Biological treatment relieves refractory skin lesions in patients with psoriasis; however, changes in the fungal microbiome (the mycobiome) on the skin are unclear. METHODS: The skin mycobiome of psoriasis patients treated with TNF inhibitors (TNFi, n = 5) and IL-17 inhibitors (IL-17i, n = 7) was compared with that of patients not receiving systemic therapy (n = 7). Skin swab samples were collected from non-lesional post-auricular areas. Fungal DNA was sequenced by ITS1 metagenomic analysis and taxonomic classification was performed. RESULTS: An average of 37543 reads/sample were analyzed and fungi belonging to 31 genera were detected. The genus Malassezia accounted for \u003e90% of reads in 7/7 samples from the no-therapy group, 4/5 from the TNFi group, and 5/7 from the IL-17i group. Biodiversity was low in those three groups. Few members of the genus trichophyton were detected; the genus Candida was not detected at all. Among the Malassezia species, M. restricta was the major species in 6/7 samples from the no-therapy group, 4/5 from the TNFi group, and 5/7 from the IL-17i group whose the other largest species revealed M. globosa. CONCLUSIONS: The mycobiome is retained on post-auricular skin during systemic treatment with TNF and IL-17 inhibitors.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "International journal of molecular sciences, 21(11), art.no.3892; 2020", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "MDPI"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.3390/ijms21113892", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "c 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "14220067", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Koike, Yuta"}], "nameIdentifiers": [{"nameIdentifier": "4111", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuwatsuka, Sayaka"}], "nameIdentifiers": [{"nameIdentifier": "4112", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishimoto, Katsutaro"}], "nameIdentifiers": [{"nameIdentifier": "4113", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Motooka, Daisuke"}], "nameIdentifiers": [{"nameIdentifier": "4114", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murota, Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": "4115", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-18"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "IJMS21_3892.pdf", "filesize": [{"value": "2.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2300000.0, "url": {"label": "IJMS21_3892.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/867/files/IJMS21_3892.pdf"}, "version_id": "6289b741-a494-4b9c-8a11-507acd0ffc00"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "biologics", "subitem_subject_scheme": "Other"}, {"subitem_subject": "fungal microbiome", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IL-17 inhibitor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mycobiome", "subitem_subject_scheme": "Other"}, {"subitem_subject": "psoriasis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TNF inhibitor", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Skin Mycobiome of Psoriasis Patients is Retained during Treatment with TNF and IL-17 Inhibitors", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Skin Mycobiome of Psoriasis Patients is Retained during Treatment with TNF and IL-17 Inhibitors"}]}, "item_type_id": "2", "owner": "2", "path": ["11"], "permalink_uri": "http://hdl.handle.net/10069/40054", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-06-19"}, "publish_date": "2020-06-19", "publish_status": "0", "recid": "867", "relation": {}, "relation_version_is_last": true, "title": ["Skin Mycobiome of Psoriasis Patients is Retained during Treatment with TNF and IL-17 Inhibitors"], "weko_shared_id": -1}
Skin Mycobiome of Psoriasis Patients is Retained during Treatment with TNF and IL-17 Inhibitors
http://hdl.handle.net/10069/40054
http://hdl.handle.net/10069/4005488f3d61e-98da-49a6-9f3e-e992542b8054
名前 / ファイル | ライセンス | アクション |
---|---|---|
IJMS21_3892.pdf (2.3 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2020-06-19 | |||||
タイトル | ||||||
タイトル | Skin Mycobiome of Psoriasis Patients is Retained during Treatment with TNF and IL-17 Inhibitors | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | biologics | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | fungal microbiome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-17 inhibitor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mycobiome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | psoriasis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TNF inhibitor | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Koike, Yuta
× Koike, Yuta× Kuwatsuka, Sayaka× Nishimoto, Katsutaro× Motooka, Daisuke× Murota, Hiroyuki |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND: Biological treatment relieves refractory skin lesions in patients with psoriasis; however, changes in the fungal microbiome (the mycobiome) on the skin are unclear. METHODS: The skin mycobiome of psoriasis patients treated with TNF inhibitors (TNFi, n = 5) and IL-17 inhibitors (IL-17i, n = 7) was compared with that of patients not receiving systemic therapy (n = 7). Skin swab samples were collected from non-lesional post-auricular areas. Fungal DNA was sequenced by ITS1 metagenomic analysis and taxonomic classification was performed. RESULTS: An average of 37543 reads/sample were analyzed and fungi belonging to 31 genera were detected. The genus Malassezia accounted for >90% of reads in 7/7 samples from the no-therapy group, 4/5 from the TNFi group, and 5/7 from the IL-17i group. Biodiversity was low in those three groups. Few members of the genus trichophyton were detected; the genus Candida was not detected at all. Among the Malassezia species, M. restricta was the major species in 6/7 samples from the no-therapy group, 4/5 from the TNFi group, and 5/7 from the IL-17i group whose the other largest species revealed M. globosa. CONCLUSIONS: The mycobiome is retained on post-auricular skin during systemic treatment with TNF and IL-17 inhibitors. | |||||
書誌情報 |
International Journal of Molecular Sciences 巻 21, 号 11, p. 3892, 発行日 2020-05-29 |
|||||
出版者 | ||||||
出版者 | MDPI | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14220067 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/ijms21113892 | |||||
権利 | ||||||
権利情報 | c 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International journal of molecular sciences, 21(11), art.no.3892; 2020 |