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Microplate analytical method for quinones by pulse photo-irradiation and chemiluminescence detection
http://hdl.handle.net/10069/31463
http://hdl.handle.net/10069/31463d0015825-e199-4636-aab9-31ac25e06a65
名前 / ファイル | ライセンス | アクション |
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Analyst137_4802.pdf (419.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-10-22 | |||||
タイトル | ||||||
タイトル | Microplate analytical method for quinones by pulse photo-irradiation and chemiluminescence detection | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | luminol | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | menadione | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | quinone derivative | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | reactive oxygen metabolite | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | article | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | blood | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chemistry | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | human | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | luminescence | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pH | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Humans | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hydrogen-Ion Concentration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Luminescent Measurements | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Luminol | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Quinones | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Reactive Oxygen Species | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Vitamin K 3 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Elgawish, Mohamed Saleh
× Elgawish, Mohamed Saleh× Shimomai, Chikako× Kishikawa, Naoya× Ohyama, Kaname× Nakashima, Kenichiro× Kuroda, Naotaka |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Quinones are widely distributed in nature and have various bioactivities. Besides, quinones are also considered as toxicological intermediates which cause severe dangerous effects. Hereby, a sensitive, simple, and rapid method is reported for quinones determination. The proposed method employed time resolved fluorescence (TRF) microplate reader based chemiluminescent (CL) detection for the first time as a novel approach for measurement. Under pulse photo-irradiation, the unique photochemical characteristic of quinones is exploited to liberate reactive oxygen species (ROS) which reacted with photosensitized CL reagent. L-012, luminol analogue, was selected for its high sensitivity. Under our investigation, para-quinones showed high CL response when compared to ortho-quinones. A linear response was obtained for studied quinone concentrations in the range of 0.05-50 μM for 1,4-naphthquinone and of 0.05-150 μM for 2-methyl-1,4-naphthoquinone (menadione) and 9,10-anthraquinone with detection limit (blank + 3SD) of 0.01 μM. The proposed method allowed the rapid determination of large number of samples in very short time (96 sample/125 s). The proposed method was successfully applied for determination of menadione in spiked human serum. | |||||
書誌情報 |
Analyst 巻 137, 号 20, p. 4802-4808, 発行日 2012-10-21 |
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出版者 | ||||||
出版者 | Royal Society of Chemistry | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00032654 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13645528 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1039/c2an35353a | |||||
権利 | ||||||
権利情報 | © 2012 The Royal Society of Chemistry. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Analyst, 137(20), pp.4802-4808; 2012 |