WEKO3
アイテム
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CXCR4-Tropic, But Not CCR5-Tropic, Human Immunodeficiency Virus Infection Is Inhibited by the Lipid Raft-Associated Factors, Acyclic Retinoid Analogs, and Cholera Toxin B Subunit
http://hdl.handle.net/10069/31581
http://hdl.handle.net/10069/31581d2116e78-2d18-431c-8c92-079ac013dd31
名前 / ファイル | ライセンス | アクション |
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AIDSRHR29_279.pdf (607.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-05-01 | |||||
タイトル | ||||||
タイトル | CXCR4-Tropic, But Not CCR5-Tropic, Human Immunodeficiency Virus Infection Is Inhibited by the Lipid Raft-Associated Factors, Acyclic Retinoid Analogs, and Cholera Toxin B Subunit | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chemokine receptor CCR5 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chemokine receptor CXCR4 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cholera toxin B subunit | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | geranylgeranoic acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | peretinoin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | retinoid derivative | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | transactivator protein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | unclassified drug | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | virus envelope protein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | virus vector | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antiviral therapy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | article | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cell viability | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | controlled study | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | human | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | human cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Human immunodeficiency virus 1 infection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lipid raft | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | membrane fusion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nonhuman | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | priority journal | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | protein depletion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | protein expression | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | target cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | viral tropism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | virus particle | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | virus strain | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kamiyama, Haruka
× Kamiyama, Haruka× Kakoki, Katsura× Shigematsu, Sayuri× Izumida, Mai× Yashima, Yuka× Tanaka, Yuetsu× Hayashi, Hideki× Matsuyama, Toshifumi× Sato, Hironori× Yamamoto, Naoki× Sano, Tetsuro× Shidoji, Yoshihiro× Kubo, Yoshinao |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Development of an effective low-cost anti-acquired immunodeficiency syndrome (AIDS) drugs is needed for treatment of AIDS patients in developing countries. Host cell lipid raft microdomains, which are enriched with cholesterol, glycolipids, ceramide, and gangliosides, are important for human immunodeficiency virus type 1 (HIV-1) entry. Retinoid analogs have been shown to modulate ceramide levels in the cell membrane, while cholera toxin B subunit (CT-B) specifically binds to the ganglioside GM1. In this study, we found that the acyclic retinoid analogs geranylgeranoic acid (GGA) and NIK-333 as well as CT-B efficiently attenuate CXCR4-tropic, but not CCR5-tropic, HIV-1 vector infection. We also found that GGA and NIK-333 suppress CXCR4-tropic HIV-1 infection by attenuating CXCR4 expression. CT-B also attenuated CXCR4-tropic HIV-1 infection, but did not suppress CXCR4 expression. These results suggest a distinct role for lipid raft microdomains in CXCR4- and CCR5-tropic HIV-1 infections and illuminate novel agents for the development of AIDS therapy. | |||||
書誌情報 |
AIDS Research and Human Retroviruses 巻 29, 号 2, p. 279-288, 発行日 2013-01-21 |
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出版者 | ||||||
出版者 | Mary Ann Liebert Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 08892229 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19318405 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1089/aid.2012.0174 | |||||
権利 | ||||||
権利情報 | This is a copy of an article published in the AIDS Research and Human Retroviruses © 2013 Mary Ann Liebert, Inc.; AIDS Research and Human Retroviruses is available online at: http://online.liebertpub.com. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | AIDS Research and Human Retroviruses, 29(2), pp.279-288; 2013 |