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Effects of a short course of pranlukast combined with systemic corticosteroid on acute asthma exacerbation induced by upper respiratory tract infection
http://hdl.handle.net/10069/29889
http://hdl.handle.net/10069/298893b9a2b8e-56cc-4b49-8dbc-e3fc0ce89d77
名前 / ファイル | ライセンス | アクション |
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JoA49_637.pdf (206.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-09-01 | |||||
タイトル | ||||||
タイトル | Effects of a short course of pranlukast combined with systemic corticosteroid on acute asthma exacerbation induced by upper respiratory tract infection | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bronchial asthma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Corticosteroid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Leukotriene receptor antagonist | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Respiratory syncytial virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Upper respiratory tract infection | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Matsuse, Hiroto
× Matsuse, Hiroto× Fukahori, Susumu× Tsuchida, Tomoko× Kawano, Tetsuya× Tomari, Shinya× Matsuo, Nobuko× Nishino, Tomoya× Fukushima, Chizu× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background. Upper respiratory tract infections (URIs) represent the most frequent cause of acute asthma exacerbation. Systemic corticosteroid (CS) is presently recommended for URI-induced asthma exacerbation, although it might inhibit cellular immunity against respiratory virus infection. Objectives. To determine the effects of adding a short course (2 weeks) of a leukotriene receptor antagonist (LTRA) to systemic CS on URI-induced acute asthma exacerbation. Methods. Twenty-three adult asthmatics (mean age, 42.8 ± 9.8 y; Male:Female, 10:13) with URI-induced acute asthma exacerbation confirmed by a questionnaire and physical findings were randomly assigned to receive either oral prednisolone (PSL) alone or oral PSL plus the LTRA pranlukast (PRL) for 2 weeks (PSL + PRL). The cumulative doses of PSL and the amount of time required to clear asthma-related symptoms were determined. Levels of respiratory syncytial virus (RSV) RNA and influenza viral (IV) antigen in nasopharyngeal swabs were also determined. Results. Adding PRL significantly reduced the cumulative dose of PSL and tended to reduce the time required to clear asthma-related symptoms. Either RSV or IV was detected in about one-third of the patients. Conclusion. The combination of an LTRA and CS might be more useful than CS alone for treating URI-induced acute exacerbation of asthma and reducing the cumulative CS dose. | |||||
書誌情報 |
Journal of Asthma 巻 49, 号 6, p. 637-641, 発行日 2012-08 |
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出版者 | ||||||
出版者 | Informa Healthcare | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 02770903 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15324303 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3109/02770903.2012.685539 | |||||
権利 | ||||||
権利情報 | © 2012 Informa Healthcare USA, Inc. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Asthma, 49(6), pp.637-641; 2012 |