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Development of a novel method for monitoring the antioxidative effect of ascorbic acid in rat blood
http://hdl.handle.net/10069/29899
http://hdl.handle.net/10069/2989902213299-8c55-4ac9-898b-f0936097bb09
名前 / ファイル | ライセンス | アクション |
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FooChe164_546.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-11-30 | |||||
タイトル | ||||||
タイトル | Development of a novel method for monitoring the antioxidative effect of ascorbic acid in rat blood | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Antioxidative effect | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ascorbic acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chemiluminescence | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Microdialysis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rat | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Semi-micro flow injection analysis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Wada, Mitsuhiro
× Wada, Mitsuhiro× Kira, Megumi× Nakaji, Yosuke× Ikeda, Rie× Kuroda, Naotaka× Nakashima, Kenichiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A real time evaluation method for the ex vivo antioxidative effect in rat blood after administration of ascorbic acid (ASA) is described. The antioxidative effect in small amounts of samples (0.5 μL) could be measured by hyphenated semi-micro flow injection analysis-chemiluminescence detection and microdialysis methods. Antioxidative effects of blood microdialysates obtained from rats administered 50 mg/kg ASA through different routes (intravein: i.v., intraperitoneal: i.p. and per os: p.o.) were evaluated. The increased effects were maintained up to 360 min after administration. The AUC 0-360 (antioxidative effect % × min) were 16,260 ± 1739 (i.v.), 12,873 ± 2152 (i.p.) and 6668 ± 2251 (p.o.). Additionally, ASA was determined to be the source of the microdialysate antioxidative effect by diminishing its effect with ascorbic acid oxidase. Furthermore, the concentration of ASA in the microdialysate was correlated with the antioxidative effect (r = 0.915). | |||||
書誌情報 |
Food Chemistry 巻 134, 号 1, p. 546-552, 発行日 2012-09 |
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出版者 | ||||||
出版者 | Elsevier Limited | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03088146 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.foodchem.2012.02.117 | |||||
権利 | ||||||
権利情報 | © 2012 Elsevier Ltd. All rights reserved. | |||||
権利 | ||||||
権利情報 | NOTICE: this is the author’s version of a work that was accepted for publication in Food Chemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Food Chemistry, 134, 1(2012) | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Food Chemistry, 134(1), pp.546-552; 2012 |