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Prognostic factors influencing clinical outcome of allogeneic hematopoietic stem cell transplantation following imatinib-based therapy in BCR–ABL-positive ALL
http://hdl.handle.net/10069/29940
http://hdl.handle.net/10069/299401de80139-f71f-4e8b-94cd-3df8c55765fe
名前 / ファイル | ライセンス | アクション |
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BCJ2_72.pdf (349.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-12-04 | |||||
タイトル | ||||||
タイトル | Prognostic factors influencing clinical outcome of allogeneic hematopoietic stem cell transplantation following imatinib-based therapy in BCR–ABL-positive ALL | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | philadelphia chromosome-positive acute lymphoblastic leukemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | imatinib | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | allogeneic hematopoietic stem cell transplantation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | prognostic factor | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Mizuta, Shuichi
× Mizuta, Shuichi× Matsuo, Keitaro× Maeda, Tomoya× Yujiri, Toshiaki× Hatta, Yoshihiro× Kimura, Yukihiko× Ueda, Yasunori× Kanamori, Heiwa× Usui, Noriko× Akiyama, Hideki× Takada, Satoru× Yokota, Akira× Takatsuka, Yoshifusa× Tamaki, Sigehisa× Imai, Kiyotoshi× Moriuchi, Yukiyoshi× Miyazaki, Yasushi× Ohtake, Shigeki× Ohnishi, Kazunori× Naoe, Tomoki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We investigated prognostic factors for the clinical outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) following imatinib-based therapy. Among 100 adult patients who were prospectively enrolled in the JALSG Ph+ALL202 study, 97 patients obtained complete remission (CR) by imatinib-combined chemotherapy, among whom 60 underwent allo-HSCT in their first CR. The probabilities of overall survival (OS) and disease-free survival (DFS) at 3 years after HSCT were 64% (95% CI, 49–76) and 58% (95% CI, 43–70), respectively. Prognostic factor analysis revealed that the major BCR–ABL transcript was the only unfavorable predictor for OS and DFS after HSCT by both univariate (HR, 3.67 (95% CI 1.49–9.08); P=0.005 and HR, 6.25 (95% CI, 1.88–20.8); P=0.003, respectively) and multivariate analyses (HR, 3.20 (95% CI, 1.21–8.50); P=0.019 and HR, 6.92 (95% CI, 2.09–22.9); P=0.002, respectively). Minimal residual disease status at the time of HSCT had a significant influence on relapse rate (P=0.015). Further study of the BCR–ABL subtype for the clinical impact on outcome of allo-HSCT in Ph+ALL is warranted. | |||||
書誌情報 |
Blood Cancer Journal 巻 2, 号 5, p. e72, 発行日 2012-06 |
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出版者 | ||||||
出版者 | Macmillan Publishers Limited | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 20445385 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/bcj.2012.18 | |||||
権利 | ||||||
権利情報 | © 2012 Macmillan Publishers Limited All rights reserved 2044-5385/12 | |||||
権利 | ||||||
権利情報 | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Blood Cancer Journal, 2(5), e72; 2012 |