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Normal range of anti?thyroid peroxidase antibody (TPO-Ab) and atherosclerosis among eu-thyroid population
http://hdl.handle.net/10069/40321
http://hdl.handle.net/10069/403211e084142-f047-4bce-b8ee-b192e179845f
名前 / ファイル | ライセンス | アクション |
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Medicine99_22214.pdf (204.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-10-08 | |||||
タイトル | ||||||
タイトル | Normal range of anti?thyroid peroxidase antibody (TPO-Ab) and atherosclerosis among eu-thyroid population | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | anti-thyroid peroxidase antibody | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | atherosclerosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | normal thyroid function | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thyroid hormone | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Shimizu, Yuji
× Shimizu, Yuji× Kawashiri, Shin-Ya× Noguchi, Yuko× Nagata, Yasuhiro× Maeda, Takahiro× Hayashida, Naomi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Anti-thyroid peroxidase antibody (TPO-Ab), which is the known cause of autoimmune thyroid disease, enhances proinflammatory cytokine responses. Since low-grade inflammation is a known risk factor for atherosclerosis, a normal range of TPO-Ab (TPO-Ab negative) could be positively associated with atherosclerosis among participants with normal thyroid function. However, no study reported the association between normal range of TPO-Ab and atherosclerosis among eu-thyroid participants. A cross-sectional study was conducted with 1165 Japanese individuals with normal thyroid function (ie, normal range of free triiodothyronine [free T3] and free thyroxine [free T4]), aged 40 to 74 years, who participated in an annual health checkup in 2014. Among the study population, 115 were diagnosed as having atherosclerosis. A normal range value of TPO-Ab titer is revealed to be positively associated with atherosclerosis; sex, age, thyroid function (free T3 and thyroid-stimulating hormone), and known cardiovascular risk factor adjusted odds ratio and 95% confidence interval of atherosclerosis for logarithmic values of TPO-Ab was 2.23 (1.11, 4.47). When we limited the analysis to participants with normal levels of thyroid-stimulating hormone, this association became slightly stronger (2.65 [1.27,5.51]). Among the eu-thyroid general population, a normal range of TPO-Ab titer is revealed to be positively associated with atherosclerosis. Even though a TPO-Ab titer is not clinically relevant and is not associated with autoimmune thyroid disease, it could influence endothelial remodeling including atherosclerosis. |
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書誌情報 |
Medicine 巻 99, 号 38, p. e22214, 発行日 2020-09-18 |
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出版者 | ||||||
出版者 | Wolters Klwer Health, Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00257974 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15365964 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1097/MD.0000000000022214 | |||||
権利 | ||||||
権利情報 | c2020 the Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CC BY-NC), where it is permissible todownload, share, remix, transform,and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Medicine, 99(38), e22214; 2020 |