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Recent Strategies for Targeted Brain Drug Delivery
http://hdl.handle.net/10069/40143
http://hdl.handle.net/10069/40143c96c38d1-480c-4a06-b210-33a0a2823191
名前 / ファイル | ライセンス | アクション |
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CPBul68_567.pdf (1.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-07-17 | |||||
タイトル | ||||||
タイトル | Recent Strategies for Targeted Brain Drug Delivery | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | blood?brain barrier | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | brain targeting | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glioma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ultrasound | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | multicolor deep imaging | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ogawa, Koki
× Ogawa, Koki× Kato, Naoya× Kawakami, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Because the brain is the most important human organ, many brain disorders can cause severe symptoms. For example, glioma, one type of brain tumor, is progressive and lethal, while neurodegenerative diseases cause severe disability. Nevertheless, medical treatment for brain diseases remains unsatisfactory, and therefore innovative therapies are desired. However, the development of therapies to treat some cerebral diseases is difficult because the blood-brain barrier (BBB) or blood-brain tumor barrier prevents drugs from entering the brain. Hence, drug delivery system (DDS) strategies are required to deliver therapeutic agents to the brain. Recently, brain-targeted DDS have been developed, which increases the quality of therapy for cerebral disorders. This review gives an overview of recent brain-targeting DDS strategies. First, it describes strategies to cross the BBB. This includes BBB-crossing ligand modification or temporal BBB permeabilization. Strategies to avoid the BBB using local administration are also summarized. Intrabrain drug distribution is a crucial factor that directly determines the therapeutic effect, and thus it is important to evaluate drug distribution using optimal methods. We introduce some methods for evaluating drug distribution in the brain. Finally, applications of brain-targeted DDS for the treatment of brain tumors, Alzheimer's disease, Parkinson's disease, and stroke are explained. | |||||
書誌情報 |
Chemical and Pharmaceutical Bulletin 巻 68, 号 7, p. 567-582, 発行日 2020-07-01 |
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出版者 | ||||||
出版者 | 日本薬学会 | |||||
出版者別言語 | ||||||
The Pharmaceutical Society of Japan | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0009-2363 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13475223 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/cpb.c20-00041 | |||||
権利 | ||||||
権利情報 | c 2020 The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Chemical & pharmaceutical bulletin, 68(7), pp.567-582; 2020 |