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The PI3K/Akt Pathway Contributes to Arenavirus Budding
http://hdl.handle.net/10069/30198
http://hdl.handle.net/10069/301986db17f12-f650-4d49-92f7-ac1b3e66576b
名前 / ファイル | ライセンス | アクション |
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JV86_4578.pdf (868.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-01-09 | |||||
タイトル | ||||||
タイトル | The PI3K/Akt Pathway Contributes to Arenavirus Budding | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 1 (1 cyano 1 methylethyl) 3 methyl 8 (3 quinolinyl)imidazo[4,5 c]quinolin 2(1h,3h) one | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | phosphatidylinositol 3 kinase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | protein kinase B | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rapamycin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | virus RNA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antiviral activity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | article | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cell culture | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | controlled study | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | drug effect | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | drug mechanism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | drug targeting | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | enzyme activity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | enzyme inhibition | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | genetic transcription | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lymphocytic choriomeningitis virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | priority journal | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | protein targeting | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RNA replication | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | virogenesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | virus entry | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | virus gene | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | virus inhibition | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | virus release | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Animals | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Arenavirus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cell Line | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cercopithecus aethiops | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chromones | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gene Expression Regulation, Viral | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Humans | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Imidazoles | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lassa virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lymphocytic choriomeningitis virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Morpholines | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Phosphatidylinositol 3-Kinases | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Proto-Oncogene Proteins c-akt | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Quinolines | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RNA, Viral | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Signal Transduction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Sirolimus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Virus Internalization | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Virus Release | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Virus Replication | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Urata, Shuzo
× Urata, Shuzo× Ngo, Nhi× de, la Torre Juan Carlos |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Several arenaviruses, chiefly Lassa virus (LASV), cause hemorrhagic fever (HF) disease in humans and pose a significant public health concern in regions where they are endemic. On the other hand, evidence indicates that the globally distributed prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen. The phosphatidylinositol 3-kinase (PI3K)/Akt pathway participates in many cellular processes, including cell survival and differentiation, and also has been shown to play important roles in different steps of the life cycles of a variety of viruses. Here we report that the inhibition of the PI3K/Akt pathway inhibited budding and to a lesser extent RNA synthesis, but not cell entry, of LCMV. Accordingly, BEZ-235, a PI3K inhibitor currently in cancer clinical trials, inhibited LCMV multiplication in cultured cells. These findings, together with those previously reported for Junin virus (JUNV), indicate that targeting the PI3K/Akt pathway could represent a novel antiviral strategy to combat human-pathogenic arenaviruses. | |||||
書誌情報 |
Journal of Virology 巻 86, 号 8, p. 4578-4585, 発行日 2012-04 |
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出版者 | ||||||
出版者 | American Society for Microbiology | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0022538X | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1128/JVI.06604-11 | |||||
権利 | ||||||
権利情報 | © 2012, American Society for Microbiology. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Virology, 86(8), pp.4578-4585; 2012 |