WEKO3
アイテム
{"_buckets": {"deposit": "0a966f98-56cf-4d17-ae18-d4bda6c2580d"}, "_deposit": {"created_by": 2, "id": "9608", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "9608"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00009608", "sets": ["30"]}, "author_link": ["38823", "38820", "38817", "38821", "38818", "38822", "38826", "38828", "38834", "38833", "38816", "38832", "38825", "38829", "38830", "38835", "38827", "38831", "38824", "38819"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageEnd": "4875", "bibliographicPageStart": "4870", "bibliographicVolumeNumber": "56", "bibliographic_titles": [{"bibliographic_title": "Antimicrobial Agents and Chemotherapy"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "This is the first report of a detailed relationship between triazole treatment history and triazole MICs for 154 Aspergillus fumigatus clinical isolates. The duration of itraconazole dosage increased as the itraconazole MIC increased, and a positive correlation was observed (r = 0.5700, P \u003c 0.0001). The number of itraconazole-naïve isolates dramatically decreased as the itraconazole MIC increased, particularly for MICs exceeding 2 μg/ml (0.5 μg/ml versus 2 μg/ml, P = 0.03). We also examined the relationship between cumulative itraconazole usage and the MICs of other azoles. A positive correlation existed between itraconazole dosage period and posaconazole MIC (r = 0.5237, P \u003c 0.0001). The number of itraconazole-naïve isolates also decreased as the posaconazole MIC increased, particularly for MICs exceeding 0.5 μg/ml (0.25 μg/ml versus 0.5 μg/ml, P = 0.004). Conversely, the correlation coefficient obtained from the scattergram of itraconazole usage and voriconazole MICs was small (r = -0.2627, P = 0.001). Susceptibility to three triazole agents did not change as the duration of voriconazole exposure changed. In addition, we carried out detailed analysis, including microsatellite genotyping, for isolates obtained from patients infected with azole-resistant A. fumigatus. We confirmed the presence of acquired resistance to itraconazole and posaconazole due to a G54 substitution in the cyp51A gene for a patient with chronic pulmonary aspergillosis after oral itraconazole therapy. We should consider the possible appearance of azole-resistant A. fumigatus if itraconazole is used for extended periods.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Antimicrobial Agents and Chemotherapy, 56(9), pp.4870-4875; 2012", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "American Society for Microbiology"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1128/AAC.00514-12", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2012, American Society for Microbiology. All Rights Reserved."}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00664804", "subitem_source_identifier_type": "ISSN"}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "10986596", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tashiro, Masato"}], "nameIdentifiers": [{"nameIdentifier": "38816", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Izumikawa, Koichi"}], "nameIdentifiers": [{"nameIdentifier": "38817", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirano, Katsuji"}], "nameIdentifiers": [{"nameIdentifier": "38818", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ide, Shotaro"}], "nameIdentifiers": [{"nameIdentifier": "38819", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mihara, Tomo"}], "nameIdentifiers": [{"nameIdentifier": "38820", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hosogaya, Naoki"}], "nameIdentifiers": [{"nameIdentifier": "38821", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takazono, Takahiro"}], "nameIdentifiers": [{"nameIdentifier": "38822", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Morinaga, Yoshitomo"}], "nameIdentifiers": [{"nameIdentifier": "38823", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Shigeki"}], "nameIdentifiers": [{"nameIdentifier": "38824", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kurihara, Shintaro"}], "nameIdentifiers": [{"nameIdentifier": "38825", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Imamura, Yoshifumi"}], "nameIdentifiers": [{"nameIdentifier": "38826", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyazaki, Taiga"}], "nameIdentifiers": [{"nameIdentifier": "38827", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishino, Tomoya"}], "nameIdentifiers": [{"nameIdentifier": "38828", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsukamoto, Misuzu"}], "nameIdentifiers": [{"nameIdentifier": "38829", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kakeya, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "38830", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamamoto, Yoshihiro"}], "nameIdentifiers": [{"nameIdentifier": "38831", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yanagihara, Katsunori"}], "nameIdentifiers": [{"nameIdentifier": "38832", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yasuoka, Akira"}], "nameIdentifiers": [{"nameIdentifier": "38833", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tashiro, Takayoshi"}], "nameIdentifiers": [{"nameIdentifier": "38834", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kohno, Shigeru"}], "nameIdentifiers": [{"nameIdentifier": "38835", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-22"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "AAC56_4870.pdf", "filesize": [{"value": "390.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 390500.0, "url": {"label": "AAC56_4870.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/9608/files/AAC56_4870.pdf"}, "version_id": "0652b03a-00dd-41f3-b066-4c847be7d0c3"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Aspergillus fumigatus", "subitem_subject_scheme": "Other"}, {"subitem_subject": "MIC", "subitem_subject_scheme": "Other"}, {"subitem_subject": "azole", "subitem_subject_scheme": "Other"}, {"subitem_subject": "resistance", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Correlation between Triazole Treatment History and Susceptibility in Clinically Isolated Aspergillus fumigatus", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Correlation between Triazole Treatment History and Susceptibility in Clinically Isolated Aspergillus fumigatus"}]}, "item_type_id": "2", "owner": "2", "path": ["30"], "permalink_uri": "http://hdl.handle.net/10069/30252", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-04-01"}, "publish_date": "2013-04-01", "publish_status": "0", "recid": "9608", "relation": {}, "relation_version_is_last": true, "title": ["Correlation between Triazole Treatment History and Susceptibility in Clinically Isolated Aspergillus fumigatus"], "weko_shared_id": -1}
Correlation between Triazole Treatment History and Susceptibility in Clinically Isolated Aspergillus fumigatus
http://hdl.handle.net/10069/30252
http://hdl.handle.net/10069/302520cc683bf-1921-49a3-878b-844012bce7d2
名前 / ファイル | ライセンス | アクション |
---|---|---|
AAC56_4870.pdf (390.5 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2013-04-01 | |||||
タイトル | ||||||
タイトル | Correlation between Triazole Treatment History and Susceptibility in Clinically Isolated Aspergillus fumigatus | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Aspergillus fumigatus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MIC | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | azole | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | resistance | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tashiro, Masato
× Tashiro, Masato× Izumikawa, Koichi× Hirano, Katsuji× Ide, Shotaro× Mihara, Tomo× Hosogaya, Naoki× Takazono, Takahiro× Morinaga, Yoshitomo× Nakamura, Shigeki× Kurihara, Shintaro× Imamura, Yoshifumi× Miyazaki, Taiga× Nishino, Tomoya× Tsukamoto, Misuzu× Kakeya, Hiroshi× Yamamoto, Yoshihiro× Yanagihara, Katsunori× Yasuoka, Akira× Tashiro, Takayoshi× Kohno, Shigeru |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | This is the first report of a detailed relationship between triazole treatment history and triazole MICs for 154 Aspergillus fumigatus clinical isolates. The duration of itraconazole dosage increased as the itraconazole MIC increased, and a positive correlation was observed (r = 0.5700, P < 0.0001). The number of itraconazole-naïve isolates dramatically decreased as the itraconazole MIC increased, particularly for MICs exceeding 2 μg/ml (0.5 μg/ml versus 2 μg/ml, P = 0.03). We also examined the relationship between cumulative itraconazole usage and the MICs of other azoles. A positive correlation existed between itraconazole dosage period and posaconazole MIC (r = 0.5237, P < 0.0001). The number of itraconazole-naïve isolates also decreased as the posaconazole MIC increased, particularly for MICs exceeding 0.5 μg/ml (0.25 μg/ml versus 0.5 μg/ml, P = 0.004). Conversely, the correlation coefficient obtained from the scattergram of itraconazole usage and voriconazole MICs was small (r = -0.2627, P = 0.001). Susceptibility to three triazole agents did not change as the duration of voriconazole exposure changed. In addition, we carried out detailed analysis, including microsatellite genotyping, for isolates obtained from patients infected with azole-resistant A. fumigatus. We confirmed the presence of acquired resistance to itraconazole and posaconazole due to a G54 substitution in the cyp51A gene for a patient with chronic pulmonary aspergillosis after oral itraconazole therapy. We should consider the possible appearance of azole-resistant A. fumigatus if itraconazole is used for extended periods. | |||||
書誌情報 |
Antimicrobial Agents and Chemotherapy 巻 56, 号 9, p. 4870-4875, 発行日 2012-09 |
|||||
出版者 | ||||||
出版者 | American Society for Microbiology | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00664804 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10986596 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1128/AAC.00514-12 | |||||
権利 | ||||||
権利情報 | © 2012, American Society for Microbiology. All Rights Reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Antimicrobial Agents and Chemotherapy, 56(9), pp.4870-4875; 2012 |