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Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade
http://hdl.handle.net/10069/30257
http://hdl.handle.net/10069/30257931f8d83-c178-4b10-8e02-e8b199d38041
名前 / ファイル | ライセンス | アクション |
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NG44_1051.pdf (913.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-01-17 | |||||
タイトル | ||||||
タイトル | Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | microsatellite DNA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | article | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cell invasion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | copy number variation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | erythrocyte | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gene duplication | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gene frequency | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gene sequence | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | genetic variability | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Haplorhini | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | malaria | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | multigene family | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nonhuman | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nucleotide sequence | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Plasmodium cynomolgi | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Plasmodium knowlesi | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Plasmodium vivax | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | priority journal | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | single nucleotide polymorphism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | unindexed sequence | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cercopithecidae | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Plasmodium cynomolgi | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Plasmodium knowlesi | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Plasmodium vivax | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Simiae | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tachibana, Shin-Ichiro
× Tachibana, Shin-Ichiro× Sullivan, Steven A× Kawai, Satoru× Nakamura, Shota× Kim, Hyunjae R× Goto, Naohisa× Arisue, Nobuko× Palacpac, Nirianne M Q× Honma, Hajime× Yagi, Masanori× Tougan, Takahiro× Katakai, Yuko× Kaneko, Osamu× Mita, Toshihiro× Kita, Kiyoshi× Yasutomi, Yasuhiro× Sutton, Patrick L× Shakhbatyan, Rimma× Horii, Toshihiro× Yasunaga, Teruo× Barnwell, John W× Escalante, Ananias A× Carlton, Jane M× Tanabe, Kazuyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | P. cynomolgi, a malaria-causing parasite of Asian Old World monkeys, is the sister taxon of P. vivax, the most prevalent malaria-causing species in humans outside of Africa. Because P. cynomolgi shares many phenotypic, biological and genetic characteristics with P. vivax, we generated draft genome sequences for three P. cynomolgi strains and performed genomic analysis comparing them with the P. vivax genome, as well as with the genome of a third previously sequenced simian parasite, Plasmodium knowlesi. Here, we show that genomes of the monkey malaria clade can be characterized by copy-number variants (CNVs) in multigene families involved in evasion of the human immune system and invasion of host erythrocytes. We identify genome-wide SNPs, microsatellites and CNVs in the P. cynomolgi genome, providing a map of genetic variation that can be used to map parasite traits and study parasite populations. The sequencing of the P. cynomolgi genome is a critical step in developing a model system for P. vivax research and in counteracting the neglect of P. vivax. | |||||
書誌情報 |
Nature Genetics 巻 44, 号 9, p. 1051-1055, 発行日 2012-09 |
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出版者 | ||||||
出版者 | Nature Publishing Group | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10614036 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15461718 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/ng.2375 | |||||
権利 | ||||||
権利情報 | © 2012 Nature America, Inc. All rights reserved. | |||||
権利 | ||||||
権利情報 | This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nature Genetics, 44(9), pp.1051-1055; 2012 |