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Comparative efficacy of antitumor necrosis factor agents and tacrolimus in naive steroid-refractory ulcerative colitis patients
http://hdl.handle.net/10069/40158
http://hdl.handle.net/10069/40158ed04a2b7-65de-43a1-b935-21d3b8f223b7
名前 / ファイル | ライセンス | アクション |
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SciRep10_12546.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-08-07 | |||||
タイトル | ||||||
タイトル | Comparative efficacy of antitumor necrosis factor agents and tacrolimus in naive steroid-refractory ulcerative colitis patients | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kitayama, Moto
× Kitayama, Moto× Akazawa, Yuko× Yoshikawa, Daisuke× Higashi, Shuntaro× Morisaki, Tomohito× Oda, Hidetoshi× Ikeda, Maho× Nakashima, Yujiro× Tabuchi, Maiko× Hashiguchi, Keiichi× Matsushima, Kayoko× Yamaguchi, Naoyuki× Kondo, Hisayoshi× Nakao, Kazuhiko× Takeshima, Fuminao |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | While retrospective studies have compared the efficacy of anti?tumour necrosis factor (TNF) agents and tacrolimus (TAC) in ulcerative colitis (UC), information regarding first-time use of these agents is limited. The aim of our study was to investigate the short- and long-term efficacy of anti-TNF agents [adalimumab (ADA) and infliximab (IFX)] and TAC in anti-TNF agent- and TAC-naive steroid-refractory UC patients. We evaluated 150 steroid-refractory UC patients receiving anti-TNF agents (IFX: n = 30, ADA: n = 41) or TAC (n = 79) at eight institutions in Japan. Clinical response rates at 8 weeks were 73.2% and 75.9% while remission rates were 30.1% and 25.3% in the anti-TNF and TAC groups, respectively. Logistic regression analysis showed the male sex and higher C-reactive protein to be independent factors for response to anti-TNF agents and TAC, respectively. Use of TAC was an independent factor for relapse. No differences in response to the treatment or relapse were observed between IFX and ADA. In conclusion, TAC and anti-TNF agents promoted similar short-term effects, but anti-TNF agents ensured better long-term outcomes at first-time treatment of steroid-refractory UC patients. | |||||
書誌情報 |
Scientific Reports 巻 10, 号 1, p. 12546, 発行日 2020-07-27 |
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出版者 | ||||||
出版者 | Springer Nature | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 20452322 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/s41598-020-68828-z | |||||
権利 | ||||||
権利情報 | c The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Scientific Reports, 10(1), art.no.12546; 2020 |