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In situ differentiation of CD8αα Τ cells from CD4 T cells in peripheral lymphoid tissues
http://hdl.handle.net/10069/30517
http://hdl.handle.net/10069/30517a88a1f6a-e083-4968-85f4-89a21376ef0e
名前 / ファイル | ライセンス | アクション |
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SciRep2_642.pdf (2.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-02-06 | |||||
タイトル | ||||||
タイトル | In situ differentiation of CD8αα Τ cells from CD4 T cells in peripheral lymphoid tissues | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nambu, Yukiko
× Nambu, Yukiko× Hayashi, Tatsunari× Jang, Kyoung-Jin× Aoki, Koji× Mano, Hiroto× Nakano, Keiko× Osato, Motomi× Takahashi, Katsu× Itoh, Katsuhiko× Teramukai, Satoshi× Komori, Toshihisa× Fujita, Jun× Ito, Yoshiaki× Shimizu, Akira× Sugai, Manabu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Mutually exclusive cell fate determination of CD4 helper or CD8 killer T cells occurs in the thymus. These T-cell subsets are not believed to redirect other lineages. Here we showed that retinoic acid and transforming growth factor-Î 21 promoted the differentiation of CD8α α T cells from CD4 T cells in a Runx3-dependent manner. These cells were inferred to belong to immunoregulatory populations because subpopulations of CD8αα+TCRαβ T cells are known to suppress activated T cells, and mice with Runx3-/-' T cells showed defects during recovery from experimental allergic encephalomyelitis. Our results demonstrate that CD4 T cells play fundamental roles in controlling immune reactions through promotion and attenuation. We accordingly anticipate that clarifying the mechanisms underlying this process will provide insights leading to autoimmune and immunodeficiency disease therapies. | |||||
書誌情報 |
Scientific Reports 巻 2, p. 00642, 発行日 2012-09-07 |
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出版者 | ||||||
出版者 | Nature Publishing Group | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 20452322 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/srep00642 | |||||
権利 | ||||||
権利情報 | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Scientific Reports, 2, 00642; 2012 |