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A Strontium-90 Sequestrant for First-Aid Treatment of Radiation Emergency
http://hdl.handle.net/10069/30605
http://hdl.handle.net/10069/30605fe137579-b1f1-4b9b-aa47-99492aa76a7e
名前 / ファイル | ライセンス | アクション |
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CPBul60_1258.pdf (663.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-02-13 | |||||
タイトル | ||||||
タイトル | A Strontium-90 Sequestrant for First-Aid Treatment of Radiation Emergency | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Polymeric adsorbent | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Radiation emergency | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Strontium-90 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Haratake, Mamoru
× Haratake, Mamoru× Hatanaka, Eisuke× Fuchigami, Takeshi× Akashi, Makoto× Nakayama, Morio |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In this study, hydrophilic porous polymer beads with phosphonic acid groups (PGMA-EGDMA-TTA-MP) were synthesized, and assessed as a radioactive strontium-90 sequestrant for the treatment of the radiation emergency. Strontium ions were rapidly absorbed into the blood from the gastrointestinal (GI) tract after oral administration to rats, and distributed to the target organ, i.e., bones. Over 40% of the administered strontium was absorbed into the blood, while the remainder was discharged in the feces within 48 h after the administration. When the PGMA-EGDMA-TTA-MP beads were administered to rats subsequent to the strontium solution, the strontium had accumulated less in the femur. Consequently, the oral administration of the PGMA-EGDMA-TTA-MP beads was effective in suppressing the absorption of strontium from the GI tract. | |||||
書誌情報 |
Chemical and Pharmaceutical Bulletin 巻 60, 号 10, p. 1258-1263, 発行日 2012-10-01 |
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出版者 | ||||||
出版者 | 日本薬学会 | |||||
出版者別言語 | ||||||
Pharmaceutical Society of Japan | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00092363 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13475223 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/cpb.c12-00430 | |||||
権利 | ||||||
権利情報 | © 2012 The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Chemical and Pharmaceutical Bulletin, 60(10), pp.1258-1263; 2012 |