WEKO3
アイテム
{"_buckets": {"deposit": "d4734735-5633-4240-aad4-4f9822c3f158"}, "_deposit": {"created_by": 2, "id": "14098", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "14098"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00014098", "sets": ["9"]}, "author_link": ["50687", "50689", "50688", "50690"], "item_2_alternative_title_19": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Roles of oxidative stress in photoaging and the pathogenesis of systemic sclerosis"}]}, "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-12-31", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "358", "bibliographicPageStart": "349", "bibliographicVolumeNumber": "29", "bibliographic_titles": [{"bibliographic_title": "日本臨床免疫学会会誌"}, {"bibliographic_title": "Japanese Journal of Clinical Immunology", "bibliographic_titleLang": "en"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "我々の皮膚は常に外界からの様々な刺激にさらされている.その刺激の代表的なものとして太陽光線中の紫外線があげられる.紫外線は皮膚癌の発生の誘因となる他に,紫外線の曝露により皮膚には光老化と称される変化が生じてくる.光老化の特徴的な変化として皮膚表面のびまん性の色素沈着と深い皺があげられるが,その変化を特徴づけるものとして皮膚真皮におけるsolar elastosisと称される膠原線維・弾性線維の変化がある.この皮膚光老化には紫外線による酸化ストレスが深く関与していると考えられている.一方,酸化ストレスが関与する全身疾患の一つとしてとして全身性強皮症(systemic sclerosis ; SSc)があげられる.SScは全身の皮膚硬化を主徴とする膠原病であるが,レイノー症状をはじめとする血管障害も病態形成に深く関与していると考えられている.本稿では,酸化ストレスが皮膚に与える影響を光老化とSScに関して我々の研究結果とこれまでの研究知見を中心に概説する.", "subitem_description_type": "Abstract"}, {"subitem_description": "Human skin is exposed to high amount of solar ultraviolet (UV) radiation, as well as to other environmental oxidants. Photoaging refers to the effect of long-term UV exposure and sun damage superimposed on intrinsically aged skin. The clinical photoaging features are dyspigmentation, laxity, wrinkles, and cutaneous malignancies. Most conspicuous photoaging change in dermis, which is caused by elastin materials accumulation, is termed “solar elastosis”. Reactive oxygen species are known to be generated by UV radiation, and play an important role of photoaging. Although the pathogenesis of systemic sclerosis (SSc) remains unknown, oxidative stress has been suggested to contribute to clinical manifestations associated with SSc, such as vascular damage including Raynaud\u0027s phenomenon. This review focuses on recent data including our data which have demonstrated the critical role of oxidative stress in photoaging and the pathogenesis of SSc.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "日本臨床免疫学会会誌, 29(6), pp.349-358; 2006", "subitem_description_type": "Other"}]}, "item_2_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "50689", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Ogawa, Fumihide"}]}, {"nameIdentifiers": [{"nameIdentifier": "50690", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Sato, Shinichi"}]}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "日本臨床免疫学会"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.2177/jsci.29.349", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright (c) 2006 日本臨床免疫学会"}]}, "item_2_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00357971", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "09114300", "subitem_source_identifier_type": "ISSN"}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "13497413", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_62": {"attribute_name": "出版者別言語", "attribute_value_mlt": [{"subitem_text_value": "The Japan Society for Clinical Immunology"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "小川, 文秀"}], "nameIdentifiers": [{"nameIdentifier": "50687", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "佐藤, 伸一"}], "nameIdentifiers": [{"nameIdentifier": "50688", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-22"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "JJCI29_349.pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1200000.0, "url": {"label": "JJCI29_349.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/14098/files/JJCI29_349.pdf"}, "version_id": "2b24b7f2-82da-45e5-9007-702b6f1f0727"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Photoaging", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Oxidative stress", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Systemic sclerosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "methionine sulfoxide reductase (MsrA)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "8-isoprostane", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "酸化ストレスと皮膚-光老化から全身性強皮症まで", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "酸化ストレスと皮膚-光老化から全身性強皮症まで"}]}, "item_type_id": "2", "owner": "2", "path": ["9"], "permalink_uri": "http://hdl.handle.net/10069/24073", "pubdate": {"attribute_name": "公開日", "attribute_value": "2010-10-05"}, "publish_date": "2010-10-05", "publish_status": "0", "recid": "14098", "relation": {}, "relation_version_is_last": true, "title": ["酸化ストレスと皮膚-光老化から全身性強皮症まで"], "weko_shared_id": 2}
酸化ストレスと皮膚-光老化から全身性強皮症まで
http://hdl.handle.net/10069/24073
http://hdl.handle.net/10069/240738e08097e-9067-4163-93e3-a23ed40aca79
名前 / ファイル | ライセンス | アクション |
---|---|---|
JJCI29_349.pdf (1.2 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2010-10-05 | |||||
タイトル | ||||||
タイトル | 酸化ストレスと皮膚-光老化から全身性強皮症まで | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Photoaging | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Oxidative stress | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Systemic sclerosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | methionine sulfoxide reductase (MsrA) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 8-isoprostane | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
小川, 文秀
× 小川, 文秀× 佐藤, 伸一 |
|||||
著者別名 | ||||||
姓名 | Ogawa, Fumihide | |||||
著者別名 | ||||||
姓名 | Sato, Shinichi | |||||
その他のタイトル | ||||||
その他のタイトル | Roles of oxidative stress in photoaging and the pathogenesis of systemic sclerosis | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 我々の皮膚は常に外界からの様々な刺激にさらされている.その刺激の代表的なものとして太陽光線中の紫外線があげられる.紫外線は皮膚癌の発生の誘因となる他に,紫外線の曝露により皮膚には光老化と称される変化が生じてくる.光老化の特徴的な変化として皮膚表面のびまん性の色素沈着と深い皺があげられるが,その変化を特徴づけるものとして皮膚真皮におけるsolar elastosisと称される膠原線維・弾性線維の変化がある.この皮膚光老化には紫外線による酸化ストレスが深く関与していると考えられている.一方,酸化ストレスが関与する全身疾患の一つとしてとして全身性強皮症(systemic sclerosis ; SSc)があげられる.SScは全身の皮膚硬化を主徴とする膠原病であるが,レイノー症状をはじめとする血管障害も病態形成に深く関与していると考えられている.本稿では,酸化ストレスが皮膚に与える影響を光老化とSScに関して我々の研究結果とこれまでの研究知見を中心に概説する. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Human skin is exposed to high amount of solar ultraviolet (UV) radiation, as well as to other environmental oxidants. Photoaging refers to the effect of long-term UV exposure and sun damage superimposed on intrinsically aged skin. The clinical photoaging features are dyspigmentation, laxity, wrinkles, and cutaneous malignancies. Most conspicuous photoaging change in dermis, which is caused by elastin materials accumulation, is termed “solar elastosis”. Reactive oxygen species are known to be generated by UV radiation, and play an important role of photoaging. Although the pathogenesis of systemic sclerosis (SSc) remains unknown, oxidative stress has been suggested to contribute to clinical manifestations associated with SSc, such as vascular damage including Raynaud's phenomenon. This review focuses on recent data including our data which have demonstrated the critical role of oxidative stress in photoaging and the pathogenesis of SSc. | |||||
書誌情報 |
日本臨床免疫学会会誌 en : Japanese Journal of Clinical Immunology 巻 29, 号 6, p. 349-358, 発行日 2006-12-31 |
|||||
出版者 | ||||||
出版者 | 日本臨床免疫学会 | |||||
出版者別言語 | ||||||
The Japan Society for Clinical Immunology | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09114300 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13497413 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00357971 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2177/jsci.29.349 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2006 日本臨床免疫学会 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 日本臨床免疫学会会誌, 29(6), pp.349-358; 2006 |