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Enhancement of antibacterial effect of quaternary ammonium with inorganic nanosheets against Enterobacter cloacae
http://hdl.handle.net/10069/39258
http://hdl.handle.net/10069/39258f35ff27f-44f9-42a6-b6a8-fa921c3ee6f4
名前 / ファイル | ライセンス | アクション |
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ISYK1134_Yoshida.pdf (780.0 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2019-07-19 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Enhancement of antibacterial effect of quaternary ammonium with inorganic nanosheets against Enterobacter cloacae | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Titanate nanosheets | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Quaternary ammonium compounds | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Enterobacter cloacae | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Antibacterial | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bactericidal | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Colloids | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
吉田, 衣里
× 吉田, 衣里 |
|||||
著者別名 | ||||||
姓名 | Yoshida, Eri | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To suppress nosocomial infections, numerous studies of quaternary ammonium cations (R4N+) to improve the antibiotic properties have been investigated. However, most of them reported developments of novel organic or polymeric materials with R4N+. To pioneer antibacterial inorganic materials hybridized with R4N+, a colloidal solution of metal oxide nanosheets, which have a small particle size (typically less than 10 nm), is considered to be a suitable option because oxide nanosheets with a negative surface charge strongly interact R4N+. Herein, we demonstrate for the first time that the high antibacterial/bactericidal effects of titanate nanosheets (TNS) adsorbing tetramethylammonium (TMA-TNS) or tetrabultylammonium ions (TBA-TNS). Their antibacterial effects against Enterobacter cloacae were evaluated using a colony forming unit (CFU) counting method. The results showed that the synthesized TNS composites had superior antibacterial and bactericidal effects to those of free R4N+ and TBA-TNS exhibited the strongest effect (69% CFU reduction compared with that of free TBA+ and 98% CFU reduction compared with the control) among the samples examined. Dark incubation was employed to ensure that photocatalytic reaction of semiconducting TNS did not contribute to the process. Compared with TiO2 spherical particles, such high bactericidal effect would be induced by a synergistic function of TBA+ and TNS, which physically damages bacteria due to long hydrophobic alkyl chains and an anisotropic nanocrystalline structure with sharp edges, respectively. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第1134号 学位授与年月日:平成31年3月20日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Author: Eri Yoshida, Murray Lawn, Takeshi Nagayasu, Kai Kamada | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Citation: Journal of Nanoparticle Research, 20, article no.199; 2018 | |||||
書誌情報 |
Journal of Nanoparticle Research 巻 20, 号 7, p. 199, 発行日 2019-03-20 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13880764 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1572896X | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s11051-018-4303-6 | |||||
権利 | ||||||
権利情報 | c Springer Nature B.V. 2018 | |||||
権利 | ||||||
権利情報 | The final publication is available at link.springer.com | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | 第4級アンモニウムと無機ナノシートを用いたエンテロバクター・クロアカに対する抗菌効果の増強 | |||||
出版者 | ||||||
出版者 | Springer Netherlands | |||||
関係URI | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10069/39023 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17301 | |||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2019-03-20 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲医歯薬第1134号 | |||||
学位の種類 | ||||||
課程博士 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2019-03-20) |