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The Efficacy of Autologous Myoblast Sheet Transplantation to Prevent Perforation After Duodenal Endoscopic Submucosal Dissection in Porcine Model
http://hdl.handle.net/10069/00040737
http://hdl.handle.net/10069/0004073739694ada-b15b-4653-baef-b8f457211245
名前 / ファイル | ライセンス | アクション |
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ISYK1301_Matsumoto.pdf (904.7 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2021-04-22 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The Efficacy of Autologous Myoblast Sheet Transplantation to Prevent Perforation After Duodenal Endoscopic Submucosal Dissection in Porcine Model | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | duodenum | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neoplasm | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | endoscopic resection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | regenerative medicine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cell sheet technology | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
松本, 亮
× 松本, 亮 |
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著者別名 | ||||||
姓名 | Matsumoto, Ryo | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The recent advent of endoscopy has enabled the endoscopic submucosal dissection (ESD) of superficial nonampullary duodenal epithelial tumors. However, the substantially thin wall and presence of bile and pancreatic juice make it technically difficult to perform duodenal ESD without perforation, which leads to lethal complications. The present study evaluated the efficacy of autologous myoblast sheet transplantation for the prevention of late perforation after duodenal ESD in a porcine model. Two weeks before ESD, skeletal muscle was surgically excised from the femur of pigs, and myoblasts were isolated and seeded in temperature-responsive culture dishes to prepare sheets. Immediately after ESD, the autologous myoblast sheets were attached to the serosal surface at the ESD site with omentopexy. The pigs were divided into two groups: the autologous myoblast sheet group (n ¼ 5), where the myoblast cell sheet was attached to the ESD ulcer part from the duodenal serous side, and the Omentum group (n ¼ 5), where only the omentum was used. The pigs were sacrificed and analyzed macroscopically and histologically on postoperative day 3. The macroscopic examination of the abdominal cavity revealed perforation in the ESD ulcer area and leakage of bile in the Omentum group but no perforation in the Sheet group. A histopathological examination revealed that continuity of the duodenal wall at the ESD site was maintained with dense connective tissue in the Sheet group. In conclusion, autologous myoblast sheets were useful for preventing perforation after duodenal ESD. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第1301号 学位授与年月日:令和3年3月3日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Author: Ryo Matsumoto, Kengo Kanetaka, Yasuhiro Maruya, Shun Yamaguchi, Shinichiro Kobayashi, Daisuke Miyamoto, Ken Ohnita, Yusuke Sakai, Keiichi Hashiguchi, Kazuhiko Nakao and Susumu Eguchi | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Citation: Cell Transplantation, 29(1–12),pp.1-12 ; 2020 | |||||
書誌情報 |
Cell Transplantation 巻 29, p. 1-12, 発行日 2021-03-03 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0963-6897 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1555-3892 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1177/0963689720963882 | |||||
権利 | ||||||
権利情報 | Copyright © by SAGE Publications Inc, unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | ブタ十二指腸内視鏡的粘膜下層剥離術モデルに対する自家筋芽細胞シートの穿孔抑制効果 | |||||
出版者 | ||||||
出版者 | SAGE Publications | |||||
関係URI | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10069/40570 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17301 | |||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2021-03-03 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲医歯薬第1301号 | |||||
学位の種類 | ||||||
課程博士 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2021-03-03) |