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Measurement of anti-suprabasin antibodies, multiple cytokines and chemokines as potential predictive biomarkers for neuropsychiatric systemic lupus erythematosus
http://hdl.handle.net/10069/00041754
http://hdl.handle.net/10069/0004175491fc1c14-6043-4942-a056-959ec0dd8ac3
名前 / ファイル | ライセンス | アクション |
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KISYK23_Hoang.pdf (1.1 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2022-09-29 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Measurement of anti-suprabasin antibodies, multiple cytokines and chemokines as potential predictive biomarkers for neuropsychiatric systemic lupus erythematosus | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Suprabasin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cytokines | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chemokines | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | NPSLE | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bayesian posterior predictive values | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | SOIL | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
Hoang, Thi Thu Trang
× Hoang, Thi Thu Trang |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Neuropsychiatric systemic lupus erythematosus (NPSLE) varies in presentation and is one of the leading causes of morbidity and mortality among patients with SLE. This study determined the most critical serum biomarkers for the development of NPSLE as they may have clinical utility prior to the onset of neuropsychiatric symptoms. We retrospectively analyzed 35 NPSLE patients, 34 SLE patients, 20 viral meningitis (VM) patients, and 16 relapsing-remitting multiple sclerosis (MS) patients. We measured anti-suprabasin antibodies concentrations in serum by using Luciferase immunoprecipitation system (LIPS) assay. The serum concentrations of cytokines/chemokines were measured by using multiplex bead-based assay. We found serum FGF-2 level was significantly higher in the NPSLE group compared to the SLE group and the healthy control group. The anti-suprabasin antibody relative concentration (SRC) has high positive predictive values for the development of NPSLE. The most essential biomarkers are VEGF, anti-suprabasin antibodies, sCD40L, IL-10, GRO, MDC, IL-8, IL-9, TNF-α, MIP-1α. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:共博(医歯薬)甲第23号 学位授与年月日:令和4年9月16日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Author: Trang T.T. Hoang, Kunihiro Ichinose, Shimpei Morimoto, Kaori Furukawa, Ly H.T. Le, Atsushi Kawakami | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Citation: Clinical Immunology, 237, art.no.108980; 2022 | |||||
書誌情報 |
Clinical Immunology 巻 237, p. 108980, 発行日 2022-09-16 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1521-6616 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.clim.2022.108980 | |||||
権利 | ||||||
権利情報 | © 2022 Elsevier Inc. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | 抗suprabasin抗体、サイトカインおよびケモカインによる神経精神ループスの診断予測バイオマーカーの可能性 | |||||
出版者 | ||||||
出版者 | Elsevier Inc. | |||||
関係URI | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10069/41579 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17301 | |||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2022-09-16 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲共医歯薬第23号 | |||||
学位の種類 | ||||||
課程博士 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2022-09-16) |