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Complete response of recurrent oral squamous cell carcinoma treated with cetuximab in combination with radiotherapy: A case series
http://hdl.handle.net/10069/00041913
http://hdl.handle.net/10069/00041913195e5880-8b14-450f-8313-ce393510b84d
名前 / ファイル | ライセンス | アクション |
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OL24_431.pdf (4.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-11-29 | |||||
タイトル | ||||||
タイトル | Complete response of recurrent oral squamous cell carcinoma treated with cetuximab in combination with radiotherapy: A case series | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cmab | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RT | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | locoregional recurrence | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PI3Kp110α | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | salvage surgery | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Naruse, Tomofumi
× Naruse, Tomofumi× Furukawa, Kohei× Miyoshi, Taro× Morishita, Kota× Otsuru, Mitsunobu× Umeda, Masahiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Salvage surgery for recurrent oral squamous cell carcinoma (OSCC) often leads to a poor quality of life (QOL). The present study described three cases that resulted in favorable locoregional control with cetuximab in combination with radiotherapy (Cmab + RT). Case 1 had regional recurrence of OSCC at the lower right mastoid area 4 months after primary surgery. Case 2 had regional recurrence of OSCC at the parotid area 7 months after primary surgery. Case 3 had local recurrence of OSCC at the masticatory muscle and Rouviere's lymph nodes 1 year and 3 months after primary surgery. In all cases, Cmab + RT was performed, and disease‑free survival was confirmed 4 months, 2 years and 6 months, and 10 months after Cmab + RT, respectively. Immunohistochemically, all resected tumors had no expression of 110‑kDa catalytic subunit of class IA phosphatidylinositol 3‑kinase (PI3Kp110α). In conclusion, if salvage surgery for recurrent OSCC results in a significantly low QOL, then shifting to chemoradiotherapy may be appropriate as a treatment strategy. In addition, strong evidence indicated that PI3Kp110α expression is associated with Cmab therapy efficacy. | |||||
書誌情報 |
Oncology Letters 巻 24, 号 6, p. 431, 発行日 2022-10-19 |
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出版者 | ||||||
出版者 | Spandidos Publications | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1792-1074 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3892/ol.2022.13551 | |||||
権利 | ||||||
権利情報 | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Oncology Letters, 24(6), art. no. 431; 2022 |