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Angiotensin receptor blocker alleviates liver fibrosis by altering the mechanotransduction properties of hepatic stellate cells
http://hdl.handle.net/10069/00042034
http://hdl.handle.net/10069/0004203404c1409c-e4db-4694-9b2d-4ef92ee2d247
名前 / ファイル | ライセンス | アクション |
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ISYK1481_Huang.pdf (5.5 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2023-02-03 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Angiotensin receptor blocker alleviates liver fibrosis by altering the mechanotransduction properties of hepatic stellate cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | angiotensin receptor blocker | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hepatic stellate cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hydrostatic pressure | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | liver fibrosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mechanotransduction | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
黄, 子圣
× 黄, 子圣 |
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著者別名 | ||||||
姓名 | HUANG, ZISHENG | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Angiotensin receptor blockers have been reported to be beneficial to liver fibrosis, but the relevant molecular and cellular mechanisms remain unclear. We herein investigated whether low-dose angiotensin receptor blocker alleviated liver fibrosis through mechanotransduction regulation. Hydrostatic pressure-induced liver fibrosis model was established in mice by ligating partially the inferior vena cava, and then randomly received a very low dose of losartan (0.5 mg/kg) or placebo treatment for 8 weeks. We found that losartan administration interfered the expression of several mechanotransductive molecules, and effectively alleviated liver fibrosis. Using a commercial device, we further confirmed that ex vivo loading of hepatic stellate cells to 50 mmHg hydrostatic pressure for 24 h significantly upregulated RhoA, ROCK, AT1R, and p-MLC2, which was effectively attenuated by adding 10 nM losartan in medium. Our in vivo and ex vivo experimental data suggest that low-dose angiotensin receptor blockers may alleviate hydrostatic pressure-induced liver fibrosis by altering the mechanotransduction properties of hepatic stellate cells. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第1481号 学位授与年月日:令和4年12月7日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Author: Zisheng Huang, Mahmoud Osman Khalifa, Peilin Li, Yu Huang, Weili Gu, and Tao-Sheng Li | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Citation: American Journal of Physiology-Gastrointestinal and Liver Physiology, 322(4), pp. G446–G456; 2022 | |||||
書誌情報 |
American Journal of Physiology-Gastrointestinal and Liver Physiology 巻 322, 号 4, p. G446-G456, 発行日 2022-12-07 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0193-1857 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1522-1547 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1152/ajpgi.00238.2021 | |||||
権利 | ||||||
権利情報 | © 2022 the American Physiological Society. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | アンジオテンシン受容体拮抗薬は、肝星細胞のメカノトランスダクション特性を変えることにより肝線維化を軽減する | |||||
出版者 | ||||||
出版者 | American Physiological Society | |||||
関係URI | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10069/00041988 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17301 | |||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2022-12-07 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲医歯薬第1481号 | |||||
学位の種類 | ||||||
課程博士 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2022-12-07) |