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Materials and Methods: This study was conducted in patients newly diagnosed with OAB. Before and 12 weeks after mirabegron treatment, we evaluated the effects on BP and PR. An overall examination was conducted, and the patients were divided into two groups according to their age: a young group (\u003c65 years old) and an old group (≥65 years old). Results: A total of 263 patients were enrolled in this study. In the overall and intragroup comparisons, the systolic BP (SBP) did not change significantly after mirabegron administration. However, an increase in SBP of ≥10 mmHg was observed in 53 (20.2%), 4 (7.4%), and 49 (23.4%) in the entire group, young group, and old group, respectively (p = 0.009). Regarding diastolic BP, a significant decrease after the treatment was detected in entire (71.2 ± 11.4 versus 69.8 ± 10.7 mmHg; p = 0.041) and old patients (71.5 ± 10.6 versus 69.5 ± 10.2 mmHg; p = 0.012). There was no significant change in PR in our study population. 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Impact of Mirabegron Administration on the Blood Pressure and Pulse Rate in Patients with Overactive Bladder
http://hdl.handle.net/10069/00042127
http://hdl.handle.net/10069/0004212770da2ca5-dc01-451f-81d8-cd90efd0d938
名前 / ファイル | ライセンス | アクション |
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ISYK1484_Ito.pdf (533.5 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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公開日 | 2023-03-22 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Impact of Mirabegron Administration on the Blood Pressure and Pulse Rate in Patients with Overactive Bladder | |||||||
言語 | ||||||||
言語 | eng | |||||||
キーワード | ||||||||
主題Scheme | Other | |||||||
主題 | blood pressure | |||||||
キーワード | ||||||||
主題Scheme | Other | |||||||
主題 | pulse rate | |||||||
キーワード | ||||||||
主題Scheme | Other | |||||||
主題 | mirabegron | |||||||
キーワード | ||||||||
主題Scheme | Other | |||||||
主題 | overactive bladder | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
資源タイプ | doctoral thesis | |||||||
アクセス権 | ||||||||
アクセス権 | open access | |||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
著者 |
伊藤, 秀德
× 伊藤, 秀德
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著者別名 | ||||||||
姓名 | Ito, Hidenori | |||||||
抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | Background and Objectives: To determine changes in the blood pressure (BP) and pulse rate (PR) before and after the administration of mirabegron in real-world clinical practice for patients with overactive bladder (OAB). Materials and Methods: This study was conducted in patients newly diagnosed with OAB. Before and 12 weeks after mirabegron treatment, we evaluated the effects on BP and PR. An overall examination was conducted, and the patients were divided into two groups according to their age: a young group (<65 years old) and an old group (≥65 years old). Results: A total of 263 patients were enrolled in this study. In the overall and intragroup comparisons, the systolic BP (SBP) did not change significantly after mirabegron administration. However, an increase in SBP of ≥10 mmHg was observed in 53 (20.2%), 4 (7.4%), and 49 (23.4%) in the entire group, young group, and old group, respectively (p = 0.009). Regarding diastolic BP, a significant decrease after the treatment was detected in entire (71.2 ± 11.4 versus 69.8 ± 10.7 mmHg; p = 0.041) and old patients (71.5 ± 10.6 versus 69.5 ± 10.2 mmHg; p = 0.012). There was no significant change in PR in our study population. Further examination using a propensity match score revealed that age was the risk factor for the increase in SBP after mirabegron administration. Conclusions: Mirabegron does not have any adverse effects on BP and PR. However, since some patients in this study had elevated SBP after administration, we suggest regular BP monitoring during mirabegron treatment. | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第1484号 学位授与年月日:令和5年3月20日 | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Author: Hidenori Ito, Tomohiro Matsuo, Kensuke Mitsunari, Kojiro Ohba and Yasuyoshi Miyata | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Citation: Medicina, 58(6), art. no. 825; 2022 | |||||||
書誌情報 |
Medicina 巻 58, 号 6, p. 825, 発行日 2023-03-20 |
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ISSN | ||||||||
収録物識別子タイプ | ISSN | |||||||
収録物識別子 | 1648-9144 | |||||||
DOI | ||||||||
識別子タイプ | DOI | |||||||
関連識別子 | 10.3390/medicina58060825 | |||||||
権利 | ||||||||
権利情報 | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
その他のタイトル | ||||||||
その他のタイトル | 過活動膀胱患者におけるミラベグロン投与前後の血圧や脈拍数に対する影響 | |||||||
出版者 | ||||||||
出版者 | MDPI | |||||||
関係URI | ||||||||
識別子タイプ | HDL | |||||||
関連識別子 | http://hdl.handle.net/10069/00042119 | |||||||
学位名 | ||||||||
学位名 | 博士(医学) | |||||||
学位授与機関 | ||||||||
学位授与機関識別子Scheme | kakenhi | |||||||
学位授与機関識別子 | 17301 | |||||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||||
学位授与年月日 | ||||||||
学位授与年月日 | 2023-03-20 | |||||||
学位授与番号 | ||||||||
学位授与番号 | 甲医歯薬第1484号 | |||||||
学位の種類 | ||||||||
課程博士 | ||||||||
引用 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2023-03-20) |