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Pathological Significance and Prognostic Role of WWC1 in Upper Urinary Tract Urothelial Cancer
http://hdl.handle.net/10069/00042128
http://hdl.handle.net/10069/000421282e4e2c12-27ef-44ed-baa2-3f43f6ab0d7e
名前 / ファイル | ライセンス | アクション |
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ISYK1485_Kurata.pdf (2.7 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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公開日 | 2023-03-22 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Pathological Significance and Prognostic Role of WWC1 in Upper Urinary Tract Urothelial Cancer | |||||||
言語 | ||||||||
言語 | eng | |||||||
キーワード | ||||||||
主題Scheme | Other | |||||||
主題 | WWC1 | |||||||
キーワード | ||||||||
主題Scheme | Other | |||||||
主題 | KIBRA | |||||||
キーワード | ||||||||
主題Scheme | Other | |||||||
主題 | tumor growth | |||||||
キーワード | ||||||||
主題Scheme | Other | |||||||
主題 | matrix metalloproteinases | |||||||
キーワード | ||||||||
主題Scheme | Other | |||||||
主題 | predictive marker | |||||||
キーワード | ||||||||
主題Scheme | Other | |||||||
主題 | upper urinary tract cancer | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
資源タイプ | doctoral thesis | |||||||
アクセス権 | ||||||||
アクセス権 | open access | |||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
著者 |
倉田, 博基
× 倉田, 博基
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著者別名 | ||||||||
姓名 | Kurata, Hiroki | |||||||
抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | Background/Aim: WW and C2 domain-containing 1 (WWC1) protein is a suppressor of malignancies. However, there is no information on the pathological significance of WWC1 in upper urinary tract cancer (UTUC). Patients and Methods: In this study, WWC1 immunoreactivity was investigated in 152 non-metastatic UTUC samples. The relationships between WWC1 expression and grade, pT stage, proliferative index (using an antibody to Ki-67), and the immunohistochemical expression of matrix metalloproteinase (MMP)-2 and -9 were evaluated. Results: WWC1 expression was negatively associated with tumor grade and pT stage (p<0.001). Positive expression of WWC1 was a better predictor of the UTUC recurrence and subsequent metastasis, and the multivariate analysis showed that WWC1 expression was a significant predictor of subsequent metastasis (hazard ratio=0.29, p=0.020). WWC1 expression inversely correlated with the proliferative index (odds ratio=2.59, p=0.023) and expression of MMP9 (odds ratio=2.19, p=0.040) but not with MMP2 expression, by multivariate analyses. Conclusion: WWC1 expression was negatively associated with malignant aggressiveness via the suppression of cancer cell proliferation and MMP9 expression in patients with UTUC. This suggests WWC1 to be a useful predictor and novel therapeutic target in patients with UTUC. | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第1485号 学位授与年月日:令和5年3月20日 | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Author: HIROKI KURATA, KENSUKE MITSUNARI, TSUBASA KONDO, MASAHITO MASATO, HIDENORI ITO, YUTA MUKAE, YUICHIRO NAKAMURA, TOMOHIRO MATSUO, KOJIRO OHBA, YASUSHI MOCHIZUKI, HIDEKI SAKAI and YASUYOSHI MIYATA | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Citation: Anticancer Research, 42(5), pp. 2311-2317; 2022 | |||||||
書誌情報 |
Anticancer Research 巻 42, 号 5, p. 2311-2317, 発行日 2023-03-20 |
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ISSN | ||||||||
収録物識別子タイプ | ISSN | |||||||
収録物識別子 | 0250-7005 | |||||||
EISSN | ||||||||
収録物識別子タイプ | ISSN | |||||||
収録物識別子 | 1791-7530 | |||||||
DOI | ||||||||
識別子タイプ | DOI | |||||||
関連識別子 | 10.21873/anticanres.15710 | |||||||
権利 | ||||||||
権利情報 | Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0). | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
その他のタイトル | ||||||||
その他のタイトル | 上部尿路上皮癌におけるWWC1の病理学的意義と診断的役割について | |||||||
出版者 | ||||||||
出版者 | International Institute of Anticancer Research | |||||||
関係URI | ||||||||
識別子タイプ | HDL | |||||||
関連識別子 | http://hdl.handle.net/10069/00042120 | |||||||
学位名 | ||||||||
学位名 | 博士(医学) | |||||||
学位授与機関 | ||||||||
学位授与機関識別子Scheme | kakenhi | |||||||
学位授与機関識別子 | 17301 | |||||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||||
学位授与年月日 | ||||||||
学位授与年月日 | 2023-03-20 | |||||||
学位授与番号 | ||||||||
学位授与番号 | 甲医歯薬第1485号 | |||||||
学位の種類 | ||||||||
課程博士 | ||||||||
引用 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2023-03-20) |