{"created":"2023-05-15T16:30:01.914969+00:00","id":1010,"links":{},"metadata":{"_buckets":{"deposit":"d32d34dc-e6d4-4f61-83c5-26943dd76cf9"},"_deposit":{"created_by":2,"id":"1010","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"1010"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00001010","sets":["8:9"]},"author_link":["4782"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-08-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"1153","bibliographicPageStart":"1147","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"Biological and Pharmaceutical Bulletin"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Gene and nucleic medicines have recently gained attention as novel drugs with the advancement of molecular biology and genetics; however, they have low bioavailability and low target delivery due to their low stability and poor membrane permeability. Therefore, the development of an effective drug delivery system (DDS) is necessary for the practical use of gene and nucleic acid medicines;however, despite considerable research, both safety and efficiency remain poor. Furthermore, the healthcare needs are not met by traditional DDS. Therefore, we developed an effective multi-functional DDS, which is constructed using materials that are safe for human consumption. This DDS involves several ternary complexes as novel gene delivery carriers constructed by coating the cationic complex of the gene and nucleic acid medicines as well as the biodegradable cationic polymer with a biocompatible anionic polymer.Early implementation of the ternary complex in clinical studies is expected due to their efficacy and safety. Furthermore, these complexes may be prepared using large-scale manufacturing. In addition, personalized DDS may be prepared according to the patient's disease stage, which is useful for advanced therapy.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Biological & pharmaceutical bulletin, 43(8), pp.1147-1153; 2020","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/bpb.b20-00156","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2020 The Pharmaceutical Society of Japan"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09186158","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13475215","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"The Pharmaceutical Society of Japan"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sasaki, Hitoshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"BPBul43_1147.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BPBul43_1147.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/1010/files/BPBul43_1147.pdf"},"version_id":"28a8a6a1-4834-432b-80e9-e188f0d67388"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"gene","subitem_subject_scheme":"Other"},{"subitem_subject":"nucleic acid","subitem_subject_scheme":"Other"},{"subitem_subject":"gene delivery","subitem_subject_scheme":"Other"},{"subitem_subject":"nanoparticle","subitem_subject_scheme":"Other"},{"subitem_subject":"ternary complex","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Development of Multi-functional Nanoparticles for Clinical Application to Gene and Nucleic Acid Medicines","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Development of Multi-functional Nanoparticles for Clinical Application to Gene and Nucleic Acid Medicines"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-08-20"},"publish_date":"2020-08-20","publish_status":"0","recid":"1010","relation_version_is_last":true,"title":["Development of Multi-functional Nanoparticles for Clinical Application to Gene and Nucleic Acid Medicines"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:09:18.326243+00:00"}