{"created":"2023-05-15T16:36:57.848609+00:00","id":10175,"links":{},"metadata":{"_buckets":{"deposit":"72b52305-8b1d-453b-9494-ec0354a2d5ee"},"_deposit":{"created_by":2,"id":"10175","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"10175"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00010175","sets":["25:26"]},"author_link":["40812","40816","40819","40820","40817","40811","40818","40814","40813","40810","40815"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-04-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageStart":"e36063","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"PLoS ONE"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The aim of the present study was to investigate chromosomal aberrations in sporadic Japanese papillary thyroid carcinomas (PTCs), concomitant with the analysis of oncogene mutational status. Twenty-five PTCs (11 with BRAF V600E, 4 with RET/PTC1, and 10 without mutation in HRAS, KRAS, NRAS, BRAF, RET/PTC1, or RET/PTC3) were analyzed using Genome-Wide Human SNP Array 6.0 which allows us to detect copy number alteration (CNA) and uniparental disomy (UPD), also referred to as copy neutral loss of heterozygosity, in a single experiment. The Japanese PTCs showed relatively stable karyotypes. Seven cases (28%) showed CNA(s), and 6 (24%) showed UPD(s). Interestingly, CNA and UPD were rarely overlapped in the same tumor; the only one advanced case showed both CNA and UPD with a highly complex karyotype. Thirteen (52%) showed neither CNA nor UPD. Regarding CNA, deletions tended to be more frequent than amplifications. The most frequent and recurrent region was the deletion in chromosome 22; however, it was found in only 4 cases (16%). The degree of genomic instability did not depend on the oncogene status. However, in oncogene-positive cases (BRAF V600E and RET/PTC1), tumors with CNA/UPD were less frequent (5/15, 33%), whereas tumors with CNA/UPD were more frequent in oncogene-negative cases (7/10, 70%), suggesting that chromosomal aberrations may play a role in the development of PTC, especially in oncogene-negative tumors. These data suggest that Japanese PTCs may be classified into three distinct groups: CNA +, UPD +, and no chromosomal aberrations. BRAF V600E mutational status did not correlate with any parameters of chromosomal defects.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"PLoS ONE, 7(4), e36063; 2012","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pone.0036063","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2012 Matsuse et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"19326203","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsuse, Michiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Kensaku"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishihara, Eijun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Minami, Shigeki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashida, Chisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kondo, Hisayoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Keiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saenko, Vladimir"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshiura, Koh-ichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mitsutake, Norisato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamashita, Shunichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"PLoS7_36063.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PLoS7_36063.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/10175/files/PLoS7_36063.pdf"},"version_id":"a5f1b708-3304-4a91-a370-5912edae823b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Copy Number Alteration and Uniparental Disomy Analysis Categorizes Japanese Papillary Thyroid Carcinomas into Distinct Groups","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Copy Number Alteration and Uniparental Disomy Analysis Categorizes Japanese Papillary Thyroid Carcinomas into Distinct Groups"}]},"item_type_id":"2","owner":"2","path":["26"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-06-25"},"publish_date":"2012-06-25","publish_status":"0","recid":"10175","relation_version_is_last":true,"title":["Copy Number Alteration and Uniparental Disomy Analysis Categorizes Japanese Papillary Thyroid Carcinomas into Distinct Groups"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T01:29:18.391243+00:00"}