{"created":"2023-05-15T16:30:02.363907+00:00","id":1020,"links":{},"metadata":{"_buckets":{"deposit":"d6407fac-9fb6-4cee-b1ce-0ec469ca0966"},"_deposit":{"created_by":6,"id":"1020","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"1020"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00001020","sets":["10:22:24"]},"author_link":["116853","116852"],"item_5_alternative_title_19":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"PTHの間歇的投与がラット脛骨に埋入されたインプラント周囲の骨量と骨質に与える影響"}]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-06-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"146","bibliographicPageStart":"139","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"Journal of Oral Biosciences"}]}]},"item_5_date_granted_64":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-06-03"}]},"item_5_degree_grantor_62":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"Nagasaki University (長崎大学)"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17301","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_61":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(歯学)"}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: Intermittent injection of parathyroid hormone (PTH) is used to treat osteoporosis. The concept of bone quality was updated 20 years ago; however, these updates have not been adopted in implant dentistry. This study aimed to investigate the effects of intermittent administration of PTH on bone quality around implants in rat tibiae. Methods: Grade IV-titanium-threaded implants that were 3.5 mm long and 2.0 mm wide were placed in a randomly selected side of the proximal tibiae of 12-week-old female Wistar rats. Three weeks after implant placement, the rats were randomly divided into PTH-administration and saline-injection groups (PTH and VC, respectively; n = 7 per group). Micro-computed tomographical, histomorphometric, and immunohistochemical analyses were performed to evaluate bone quality and quantity surrounding the implants. \nResults: PTH significantly increased bone volume and bone mineral density in bones not associated with the implants as compared to these values in the VC group. PTH significantly increased bone area and the amount of collagen within the total inside areas of all implant threads compared to that observed in VC. Moreover, PTH significantly increased the number of osteoblasts, osteocytes, and osteoclasts in the total inside and/or outside areas of all implant threads and altered the ratio of type I and III collagen to total collagen fibers. \nConclusions: Within the limitations of this study, intermittent administration of PTH improved both bone quantity and bone quality based on the types and numbers of bone cells and the types of collagen fibers surrounding implants placed into rat tibiae.","subitem_description_type":"Abstract"}]},"item_5_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"長崎大学学位論文 学位記番号:博(医歯薬)甲第1258号 学位授与年月日:令和2年6月3日","subitem_description_type":"Other"},{"subitem_description":"Author: Yusuke Uchida, Shinichiro Kuroshima, Yusuke Uto, Riho Kanai, Maaya Inoue, Masayoshi Suzue, Takashi Sawase","subitem_description_type":"Other"},{"subitem_description":"Citation: Journal of Oral Biosciences, 62(2), pp.139-146; 2020","subitem_description_type":"Other"}]},"item_5_description_69":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Nagasaki University (長崎大学), 博士(歯学) (2020-06-03)","subitem_description_type":"Other"}]},"item_5_dissertation_number_65":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医歯薬第1258号"}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"116853","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Uchida, Yusuke"}]}]},"item_5_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"歯科基礎医学会"}]},"item_5_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.job.2020.03.001","subitem_relation_type_select":"DOI"}}]},"item_5_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10069/40085","subitem_relation_type_select":"HDL"}}]},"item_5_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2020 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights reserved."}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13490079","subitem_source_identifier_type":"ISSN"}]},"item_5_text_67":{"attribute_name":"学位の種類","attribute_value_mlt":[{"subitem_text_value":"課程博士"}]},"item_5_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"内田, 悠介"}],"nameIdentifiers":[{"nameIdentifier":"116852","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-02-02"}],"displaytype":"detail","filename":"ISYK1258_Uchida.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ISYK1258_Uchida.pdf","objectType":"fulltext","url":"https://nagasaki-u.repo.nii.ac.jp/record/1020/files/ISYK1258_Uchida.pdf"},"version_id":"850058cf-8843-4eb2-917b-230c15caabca"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Bone quality","subitem_subject_scheme":"Other"},{"subitem_subject":"Bone cells","subitem_subject_scheme":"Other"},{"subitem_subject":"Parathyroid hormone","subitem_subject_scheme":"Other"},{"subitem_subject":"Implant","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Intermittent administration of parathyroid hormone improves bone quality and quantity around implants in rat tibiae","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Intermittent administration of parathyroid hormone improves bone quality and quantity around implants in rat tibiae","subitem_title_language":"en"}]},"item_type_id":"5","owner":"6","path":["24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-08-25"},"publish_date":"2020-08-25","publish_status":"0","recid":"1020","relation_version_is_last":true,"title":["Intermittent administration of parathyroid hormone improves bone quality and quantity around implants in rat tibiae"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-08-23T04:56:53.146162+00:00"}