{"created":"2023-05-15T16:30:02.578033+00:00","id":1025,"links":{},"metadata":{"_buckets":{"deposit":"800ed2f0-fb9a-4e63-845d-c97cb5c63793"},"_deposit":{"created_by":2,"id":"1025","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"1025"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00001025","sets":["12:13"]},"author_link":["4858","4860","4862","4855","4857","4859","4856","4853","4861","4854"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-08-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"65","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"Tropical Medicine and Health"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The emergence of multidrug-resistant (MDR) and extended-spectrum beta-lactamase (ESBL)-producing uropathogens has \n]complicated the treatment of urinary tract infections (UTI). Paediatric UTI is a common illness, which if not treated properly,\n may lead to acute and long-term complications, such as renal abscess, septicaemia, and renal scarring. This study aimed to determine the prevalence of MDR and ESBL-producing uropathogens among children. Methods: During the study period (April 2017-April 2018), midstream urine samples were collected following aseptic procedures from children < 16 years in Siddhi Memorial Hospital. Standard culture and biochemical tests were performed to identify uropathogens and antimicrobial susceptibility test was done by modified Kirby-Bauer disc diffusion method following Clinical and Laboratory Standard Institute (CLSI) guidelines. ESBL-producing uropathogens were screened by ceftazidime (30 μg) and cefotaxime (30 μg) discs, and confirmed by the combination disc tests: ceftazidime + clavulanic acid (30/10 μg) or cefotaxime + clavulanic acid (30/10 μg) as recommended by CLSI. Results: We processed 5545 non-repeated urine samples from the children with symptoms of UTI. A significant growth of uropathogens was observed in 203 samples (3.7%). The median age of the children was 24 months (interquartile range (IQR), 12-53 months). Escherichia coli\n (n = 158, 77.8%) and Klebsiella pneumoniae (n = 30, 14.8%) were common among the uropathogens. Among them, 80.3% were resistant to amoxycillin and 51.2% were resistant to cotrimoxazole. Most of them were susceptible to amikacin,nitrofurantoin, \nand ofloxacin. MDR was detected in 34.5% (n = 70/203) and ESBL producers in 24.6% (n = 50/203) of them. The proportion of \nMDR isolates was higher in children < 5 years (n = 59/153, 38.6%) than children ? 5 years (n = 11/50, 22%) (P = 0.03). Conclusions:Nitrofurantoin, ofloxacin, and amikacin can be used for the empirical treatment for UTI in children in Bhaktapur, Nepal.MDR and ESBL-producing uropathogens are prevalent; this warrants a continuous surveillance of antimicrobial resistance.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Tropical Medicine and Health, 48(1), art.no.65; 2020","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central Ltd"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s41182-020-00251-6","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"cThe Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License,which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13494147","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Raya, Ganendra Bhakta"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Dhoubhadel, Bhim Gopal"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shrestha, Dhruba"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Raya, Sunayana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Laghu, Ujjwal"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shah, Ashok"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Raya, Bijendra Bhakta"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kafle, Rita"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Parry, Christopher M."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ariyoshi, Koya"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"TMH48_65.pdf","filesize":[{"value":"772.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"TMH48_65.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/1025/files/TMH48_65.pdf"},"version_id":"2877d99a-72b6-4b2f-92e6-51665d75300d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Children","subitem_subject_scheme":"Other"},{"subitem_subject":"E. coli","subitem_subject_scheme":"Other"},{"subitem_subject":"Extended-spectrum beta-lactamase","subitem_subject_scheme":"Other"},{"subitem_subject":"K. pneumoniae","subitem_subject_scheme":"Other"},{"subitem_subject":"Multidrug-resistance","subitem_subject_scheme":"Other"},{"subitem_subject":"Nepal","subitem_subject_scheme":"Other"},{"subitem_subject":"Urinary tract infection","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Multidrug-resistant and extended-spectrum beta-lactamase-producing uropathogens in children in Bhaktapur, Nepal","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Multidrug-resistant and extended-spectrum beta-lactamase-producing uropathogens in children in Bhaktapur, Nepal"}]},"item_type_id":"2","owner":"2","path":["13"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-08-25"},"publish_date":"2020-08-25","publish_status":"0","recid":"1025","relation_version_is_last":true,"title":["Multidrug-resistant and extended-spectrum beta-lactamase-producing uropathogens in children in Bhaktapur, Nepal"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:08:58.232326+00:00"}