| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2012-08-09 |
| タイトル |
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|
タイトル |
The expression of TGFβ1 mRNA in the early stage of the midpalatal suture cartilage expansion |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Transforming growth factor β1 |
| キーワード |
|
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主題Scheme |
Other |
|
主題 |
Proliferation |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
Differentiation |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
Osteoblast |
| キーワード |
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主題Scheme |
Other |
|
主題 |
In-situ hybridization |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Kobayashi, Emilia Teruko
Shibata, Yasuaki
Veltrini, Vanessa Cristina
Suguino, Rosely
Machado, Fabricio Monteiro de Castro
Provenzano, Maria Gisette Arias
Ferronato, Tatiane
Kato, Yuzo
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
INTRODUCTION: The application of an orthodontic expansion force induces bone formation at the midpalatal suture because of cell proliferation and differentiation. Expansion forces may stimulate the production of osteoinductive cytokines, such as transforming growth factor β1 (TGFβ1), in the progenitor cells. OBJECTIVES: This study determined the role of TGFβ1 in the early stage of midpalatal suture cartilage expansion. METHODS: A rectangular orthodontic appliance was placed between the right and left upper molars of 4-week-old rats. The initial expansion force was 50 g. Animals in the control and experimental groups were sacrified on days 0, 2, and 5 and 6 µmm thick sections were prepared for an in situ hybridization technique. RESULTS: Two days after the application of force, prechondroblastic and undifferentiated mesenchymal cells distributed along the inner side of the cartilaginous tissue had high levels of TGFβ1 transcription. On day 5, the TGFβ1 transcription was found in osteocytes and osteoblastic cells on the surface of newly formed bone. Immunohistochemistry using Osteocalcin-Pro (OC-Pro) confirmed osteoblastic activity. Conclusions: Results suggest that the expansion of midpalatal suture cartilage induces differentiation of osteochondroprogenitor cells into osteoblasts after stimulation by cytokine production |
| 書誌情報 |
Dental Press Journal of Orthodontics
巻 15,
号 6,
p. 93-99,
発行日 2010-11
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| 出版者 |
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出版者 |
Dental Press |
| EISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
21769451 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1590/S2176-94512010000600012 |
| 権利 |
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|
権利情報 |
Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Dental Press Journal of Orthodontics, 15(6), pp.93-99; 2010 |
DPJO15_93.pdf (361.6 kB)
