{"created":"2023-05-15T16:30:03.778075+00:00","id":1053,"links":{},"metadata":{"_buckets":{"deposit":"0a69ddd1-a16a-40ba-a459-d5643931a80b"},"_deposit":{"created_by":2,"id":"1053","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"1053"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00001053","sets":["8:9"]},"author_link":["5021","5020","5026","5025","5027","5023","5031","5028","5032","5022","5024","5029","5030"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"2155","bibliographicPageStart":"2148","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"Experimental and Therapeutic Medicine"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Over 30 years have passed since co-infection with human immunodeficiency virus (HIV)/hepatitis C virus (HCV) was first documented in hemophilia patients in Japan. In such cases, the leading cause of mortality is reportedly HCV-associated end-stage liver disease. However, the current characteristics of hemophilia patients co-infected with HIV/HCV are unknown. The aim of the present study was to reveal the current characteristics, notably HCV geno-prevalence and liver function, among hemophilia patients co-infected with HIV/HCV in Japan. Current characteristics were evaluated using cross-sectional retrospective data of 44 hemophilia patients positive for anti-HCV and anti-HIV antibodies who underwent screening of liver dysfunction. A total of 56.8% of hemophilia patients co-infected with HIV/HCV were positive for HCV RNA. The most common HCV genotypes were 1a, 1b and 3a. Liver cirrhosis was diagnosed in 26.3% patients negative for HCV RNA and 60.0% patients positive for HCV RNA. Decompensated liver cirrhosis was diagnosed in 33.3% HCV RNA-positive patients and none of the HCV RNA-negative patients. The rate of liver cirrhosis was greater for HCV genotype 3a compared with other genotypes. Overall, the current primary HCV RNA genotypes among hemophilia patients co-infected with HIV/HCV are 1a, 1b and 3a. Over 50% of HIV/HCV co-infected hemophilia patients positive for HCV RNA were diagnosed with liver cirrhosis and some were diagnosed with decompensated liver cirrhosis.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Experimental and Therapeutic Medicine, 15(2), pp.2148-2155; 2018","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3892/etm.2017.5603","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2018, Spandidos Publications. All rights reserved."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"17920981","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"17921015","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miuma, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hidaka, Masaaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takatsuki, Mitsuhisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Natsuda, Koji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Soyama, Akihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyaaki, Hisamitsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kanda, Yasuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tamada, Yoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibata, Hidetaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ozawa, Eisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Taura, Naota"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Eguchi, Susumu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakao, Kazuhiko"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"ETM15_2148.pdf","filesize":[{"value":"598.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ETM15_2148.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/1053/files/ETM15_2148.pdf"},"version_id":"58cb1ccb-1809-49e4-b8bc-fb4c8e9131bc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Genotype","subitem_subject_scheme":"Other"},{"subitem_subject":"Hemophilia","subitem_subject_scheme":"Other"},{"subitem_subject":"Hepatitis C virus","subitem_subject_scheme":"Other"},{"subitem_subject":"Human immunodeficiency virus","subitem_subject_scheme":"Other"},{"subitem_subject":"Livercirrhosis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Current characteristics of hemophilia patients co?infected with HIV/HCV in Japan","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Current characteristics of hemophilia patients co?infected with HIV/HCV in Japan"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-09-01"},"publish_date":"2018-09-01","publish_status":"0","recid":"1053","relation_version_is_last":true,"title":["Current characteristics of hemophilia patients co?infected with HIV/HCV in Japan"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:08:27.217902+00:00"}