{"created":"2023-05-15T16:37:13.813534+00:00","id":10548,"links":{},"metadata":{"_buckets":{"deposit":"f06ccdaf-bb74-4ec9-8e37-afbdadfa10f2"},"_deposit":{"created_by":2,"id":"10548","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"10548"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00010548","sets":["8:9"]},"author_link":["41805","41804","41806","41808","41809","41807"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-03-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"28","bibliographicPageEnd":"9","bibliographicPageStart":"1","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Cardiovascular Diabetology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The current study was carried out to determine whether fasudil hydrochloride (fasudil), a Rho-kinase inhibitor, has myocardial postconditioning (PostC) activity under hyperglycemia as well as normoglycemia, and if so, whether the effects could be mediated by mitochondrial ATP-sensitive potassium (m-KATP) channels.Methods: Male Sprague-Dawley rats were anesthetized with sodium pentobarbital. After opening the chest, all rats underwent 30-min coronary artery occlusion followed by 2-h reperfusion. The rats received low-dose (0.15 mg/kg) or high-dose (0.5 mg/kg) fasudil or diazoxide, an m-KATP channel opener, at 10 mg/kg, just before reperfusion under normoglycemic or hyperglycemic conditions. In another group, rats received 5-hydroxydecanoic acid (5HD), an m-KATP channel blocker, at 10 mg/kg, before high-dose fasudil. Myocardial infarct size was expressed as a percentage of area at risk (AAR).Results: Under normoglycemia, low-dose and high-dose fasudil and diazoxide reduced myocardial infarct size (23 ± 8%, 21 ± 9% and 21 ± 10% of AAR, respectively) compared with that in the control (42 ± 7%). Under hyperglycemia, low-dose fasudil (40 ± 11%) and diazoxide (44 ± 14%) could not exert this beneficial effect, but high-dose fasudil reduced myocardial infarct size in the same manner as under normoglycemia (21 ± 13%). 5HD prevented fasudil-induced reduction of myocardial infarct size (42 ± 13%).Conclusion: Fasudil induces PostC against myocardial infarction via activation of m-KATP channels in the rat. Although hyperglycemia attenuates the PostC, high-dose fasudil can restore cardioprotection.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Cardiovascular Diabetology, 11(28), pp.1-9; 2012","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/1475-2840-11-28","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2012 Ichinomiya et al; licensee BioMed Central Ltd."},{"subitem_rights":"This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"14752840","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ichinomiya, Taiga"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Cho, Sungsam"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higashijima, Ushio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Shuhei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maekawa, Takuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sumikawa, Koji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"CarDia11_28.pdf","filesize":[{"value":"769.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CarDia11_28.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/10548/files/CarDia11_28.pdf"},"version_id":"28cb1dc3-ff59-447a-801c-602ffe4703ca"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Fasudil","subitem_subject_scheme":"Other"},{"subitem_subject":"Hyperglycemia","subitem_subject_scheme":"Other"},{"subitem_subject":"Mitochondrial KATP channels","subitem_subject_scheme":"Other"},{"subitem_subject":"Myocardial infarction","subitem_subject_scheme":"Other"},{"subitem_subject":"Postconditioning","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: Role of mitochondrial KATP channels","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: Role of mitochondrial KATP channels"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-08-24"},"publish_date":"2012-08-24","publish_status":"0","recid":"10548","relation_version_is_last":true,"title":["High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: Role of mitochondrial KATP channels"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T01:25:52.988889+00:00"}