{"created":"2023-05-15T16:30:03.863637+00:00","id":1055,"links":{},"metadata":{"_buckets":{"deposit":"452db1de-6b22-4d9d-afe5-dadf11906e20"},"_deposit":{"created_by":2,"id":"1055","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"1055"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00001055","sets":["10:11"]},"author_link":["5036","5042","5045","5035","5037","5043","5046","5038","5041","5044","5039","5040"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"16","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"Environmental Health and Preventive Medicine"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hepatocyte growth factor (HGF) may act as a possible biochemical index for vascular damage, although evidence for the association between HGF and carotid intima-media thickness (CIMT) is limited. Since both HGF and circulating CD34-positive cells play an important role in endothelial repair, circulating CD34-positive cell levels may influence the association between HGF and CIMT. Methods: We conducted a cross-sectional study of 269 elderly Japanese men aged 60-69 years who had undertaken an annual medical checkup from 2014 to 2015. Results: The median value for circulating CD34-positive cells was 0.93 cells/μL. Among the study population, 135 men showed low circulating CD34-positive cell levels (? 0.93 cells/μL). By multivariable linear regression analysis, HGF was found to be significantly positively associated with CIMT only to participants with low circulating CD34-positive cell levels, with a multi-adjusted β of 0.26 (p = 0.005) and 0.002 (0.986) for low and high circulating CD34-positive cell levels, respectively. In addition, a significant interaction was observed between HGF and circulating CD34-positive cell levels (low and high) on CIMT (multivariable p value of 0.049). A positive association exists between HGF and CIMT in elderly Japanese men, limited to participants with low circulating CD34-positive cell levels. Conclusion: A positive association exists between HGF and CIMT in community-dwelling elderly Japanese men, which is limited to participants with low numbers of circulating CD34-positive cells. Our findings indicate that circulating CD34-positive cell levels could determine the influence of HGF on CIMT in elderly Japanese men.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Environmental Health and Preventive Medicine, 23, 16; 2018","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central Ltd"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s12199-018-0705-4","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2018 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and\nreproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver\n(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1342078X","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13474715","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimizu, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Shimpei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koyamatsu, Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamanashi, Hirotomo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagayoshi, Mako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawashiri, Shin-Ya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inoue, Keita"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukui, Shoichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kondo, Hideaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamichi, Seiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagata, Yasuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maeda, Takahiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"EHPM23_16.pdf","filesize":[{"value":"765.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"EHPM23_16.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/1055/files/EHPM23_16.pdf"},"version_id":"7bf0f0a4-fc7e-4721-9d27-6547921a2087"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CD34-positive cell","subitem_subject_scheme":"Other"},{"subitem_subject":"CIMT","subitem_subject_scheme":"Other"},{"subitem_subject":"Elderly men","subitem_subject_scheme":"Other"},{"subitem_subject":"Endothelial repair","subitem_subject_scheme":"Other"},{"subitem_subject":"HGF","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Hepatocyte growth factor and carotid intima-media thickness in relation to circulating CD34-positive cell levels","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hepatocyte growth factor and carotid intima-media thickness in relation to circulating CD34-positive cell levels"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-11"},"publish_date":"2018-06-11","publish_status":"0","recid":"1055","relation_version_is_last":true,"title":["Hepatocyte growth factor and carotid intima-media thickness in relation to circulating CD34-positive cell levels"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:08:22.688915+00:00"}