@article{oai:nagasaki-u.repo.nii.ac.jp:00010551, author = {Mizuta, Satoshi and Onomura, Osamu}, issue = {6}, journal = {RSC Advances}, month = {Mar}, note = {A highly diastereoselective synthesis of 2,3-disubstituted piperidines has been accomplished through nucleophilic additions to N-acyliminium ions with aryl- and alkenyl boronic acids. A reversal of stereoselectivity depending on a β-substituent on the piperidine ring was observed in the alkenylation reactions with (E)-styrylboronic acid. Our strategy was applied in the key step for the synthesis of the neurokinin NK1 receptor antagonist (±)-L-733, 060., RSC Advances, 2(6), pp.2266-2269; 2012}, pages = {2266--2269}, title = {Diastereoselective addition to N-acyliminium ions with aryl- and alkenyl boronic acids via a Petasis-type reaction}, volume = {2}, year = {2012} }