{"created":"2023-05-15T16:37:14.146860+00:00","id":10556,"links":{},"metadata":{"_buckets":{"deposit":"88f2db2f-99b4-4cde-b21d-882b34a6c60b"},"_deposit":{"created_by":2,"id":"10556","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"10556"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00010556","sets":["35:36"]},"author_link":["41853","41855","41852","41854","41849","41851","41847","41856","41850","41845","41848","41846"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-03-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageStart":"e1587","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"PLoS Neglected Tropical Diseases"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Chagas disease, caused by the flagellate parasite Trypanosoma cruzi affects 8-10 million people in Latin America. The mechanisms that underlie the development of complications of chronic Chagas disease, characterized primarily by pathology of the heart and digestive system, are not currently understood. To identify possible host genetic factors that may influence the clinical course of Chagas disease, Human Leucocyte Antigen (HLA) regional gene polymorphism was analyzed in patients presenting with differing clinical symptoms. Methodology: Two hundred and twenty nine chronic Chagas disease patients in Santa Cruz, Bolivia, were examined by serological tests, electrocardiogram (ECG), and Barium enema colon X-ray. 31.4% of the examinees showed ECG alterations, 15.7% megacolon and 58.1% showed neither of them. A further 62 seropositive megacolon patients who had undergone colonectomy due to acute abdomen were recruited. We analyzed their HLA genetic polymorphisms (HLA-A, HLA-B, MICA, MICB, DRB1 and TNF-alpha promoter region) mainly through Sequence based and LABType SSO typing test using LUMINEX Technology. Principal Findings: The frequencies of HLA-DRB1*01 and HLA-B*14:02 were significantly lower in patients suffering from megacolon as well as in those with ECG alteration and/or megacolon compared with a group of patients with indeterminate symptoms. The DRB1*0102, B*1402 and MICA*011 alleles were in strong Linkage Disequilibrium (LD), and the HLA-DRB1*01-B*14-MICA*011haplotype was associated with resistance against chronic Chagas disease. Conclusions: This is the first report of HLA haplotype association with resistance to chronic Chagas disease.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"PLoS Neglected Tropical Diseases, 6(3), e1587; 2012","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pntd.0001587","subitem_relation_type_select":"DOI"}}]},"item_2_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://hdl.handle.net/10069/29739"}]}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2012 del Puerto et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"19352735","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Del, Puerto  Florencia"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishizawa, Juan Eiki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kikuchi, Mihoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Roca, Yelin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Avilas, Cinthia"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Gianella, Alberto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Lora, Javier"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Velarde, Freddy Udalrico Gutierrez"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miura, Sachio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Komiya, Norihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maemura, Koji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirayama, Kenji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"PLoSNeg6_1587.pdf","filesize":[{"value":"107.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PLoSNeg6_1587.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/10556/files/PLoSNeg6_1587.pdf"},"version_id":"21afa694-7879-4a90-81a9-3c411d12271a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Protective Human Leucocyte Antigen Haplotype, HLA-DRB1*01-B*14, against Chronic Chagas Disease in Bolivia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Protective Human Leucocyte Antigen Haplotype, HLA-DRB1*01-B*14, against Chronic Chagas Disease in Bolivia"}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-08-27"},"publish_date":"2012-08-27","publish_status":"0","recid":"10556","relation_version_is_last":true,"title":["Protective Human Leucocyte Antigen Haplotype, HLA-DRB1*01-B*14, against Chronic Chagas Disease in Bolivia"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T01:25:40.703016+00:00"}