@article{oai:nagasaki-u.repo.nii.ac.jp:00010635,
 author = {Sakai, Kazuyuki and Cho, Sungsam and Shibata, Itsuko and Yoshitomi, Osamu and Maekawa, Takuji and Sumikawa, Koji},
 issue = {3},
 journal = {Scandinavian Cardiovascular Journal},
 month = {Jun},
 note = {Objectives. The present study was carried out to determine whether inhalation of hydrogen (H 2) gas protects myocardium against ischemia-reperfusion (I/R) injury in swine. Design. In anesthetized open-chest swine, myocardial stunning was produced by 12-minute occlusion of left anterior descending coronary artery (LAD) followed by 90-minute reperfusion in the first study. Group A inhaled 100% oxygen, and group B inhaled 2% H 2 plus 98% oxygen during ischemia and reperfusion. In the second study, myocardial infarction was produced by 40-minute occlusion of LAD followed by 120-minute reperfusion. Group C inhaled 100% oxygen during ischemia and reperfusion. Group D inhaled 2% H 2 plus 98% oxygen. Group E inhaled 4% H 2 plus 96% oxygen. Results. The change of segment shortening (%SS) from baseline at 90 minutes after reperfusion in group B was 74±13 (mean ± SD) %, which was significantly higher than that in group A (48±15%). Myocardial infarct size in group E (32±10%), but not in group D (40±9%) was smaller than that in group C (46±6%). Conclusions. Inhalation of 2% H 2 gas improves myocardial stunning, and inhalation of 4% but not 2% H 2 gas reduces myocardial infarct size in swine., Scandinavian Cardiovascular Journal, 46(3), pp.183-188; 2012},
 pages = {183--188},
 title = {Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine},
 volume = {46},
 year = {2012}
}