{"created":"2023-05-15T16:37:18.511982+00:00","id":10659,"links":{},"metadata":{"_buckets":{"deposit":"52d5e4b8-0437-4764-975e-587579279bca"},"_deposit":{"created_by":2,"id":"10659","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"10659"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00010659","sets":["10:11"]},"author_link":["42105","42107","42109","42110","42104","42111","42112","42108","42106"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"1604","bibliographicPageStart":"1597","bibliographicVolumeNumber":"132","bibliographic_titles":[{"bibliographic_title":"Journal of Investigative Dermatology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Keloids are a fibroproliferative disease due to abnormal wound healing process after skin injury. They are characterized by overproduction of extracellular matrix (ECM) such as collagens. MicroRNAs (miRNAs) are noncoding small RNAs and negatively regulate protein expression. Several miRNAs that have critical roles in tissue fibrosis and ECM metabolism have been reported. However, regulation and function of miRNAs in keloid remain to be explored. The purpose of this study was to identify miRNAs involved in keloid pathogenesis. We performed miRNA microarray analysis to compare miRNA expression profiles between keloid-derived fibroblasts (KFs) and normal fibroblasts (NFs). In all, 7 upregulated and 20 downregulated miRNAs were identified. Among these, we focused on miR-196a, which showed the highest fold change. Overexpression or knockdown of miR-196a led to a decreased or increased level of secreted type I/III collagens, respectively. Reporter analysis showed direct binding of miR-196a to the 3′ untranslated region (UTR) of COL1A1 and COL3A1. In conclusion, we demonstrate for the first time that miRNA expression profile is altered in KFs compared with NFs. Downregulation of miR-196a may be one of the mechanisms by which collagens are highly deposited in keloid tissues. Our findings suggest that miR-196a could be a new therapeutic target for keloid lesions.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Investigative Dermatology, 132(6), pp.1597-1604; 2012","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/jid.2012.22","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2012 The Society for Investigative Dermatology."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022202X","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"15231747","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kashiyama, Kazuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mitsutake, Norisato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuse, Michiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogi, Tomoo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saenko, Vladimir A"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ujifuku, Kenta"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Utani, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirano, Akiyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamashita, Shunichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"JID132_1597.pdf","filesize":[{"value":"3.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JID132_1597.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/10659/files/JID132_1597.pdf"},"version_id":"e5988310-e33c-47d5-9351-3ab36174e699"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"collagen type 1","subitem_subject_scheme":"Other"},{"subitem_subject":"collagen type 3","subitem_subject_scheme":"Other"},{"subitem_subject":"corticosteroid","subitem_subject_scheme":"Other"},{"subitem_subject":"microRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"microRNA 196a","subitem_subject_scheme":"Other"},{"subitem_subject":"tranilast","subitem_subject_scheme":"Other"},{"subitem_subject":"unclassified drug","subitem_subject_scheme":"Other"},{"subitem_subject":"3' untranslated region","subitem_subject_scheme":"Other"},{"subitem_subject":"acne","subitem_subject_scheme":"Other"},{"subitem_subject":"adolescent","subitem_subject_scheme":"Other"},{"subitem_subject":"adult","subitem_subject_scheme":"Other"},{"subitem_subject":"aged","subitem_subject_scheme":"Other"},{"subitem_subject":"article","subitem_subject_scheme":"Other"},{"subitem_subject":"blister","subitem_subject_scheme":"Other"},{"subitem_subject":"clinical article","subitem_subject_scheme":"Other"},{"subitem_subject":"controlled study","subitem_subject_scheme":"Other"},{"subitem_subject":"down regulation","subitem_subject_scheme":"Other"},{"subitem_subject":"electron therapy","subitem_subject_scheme":"Other"},{"subitem_subject":"female","subitem_subject_scheme":"Other"},{"subitem_subject":"fibroblast","subitem_subject_scheme":"Other"},{"subitem_subject":"human","subitem_subject_scheme":"Other"},{"subitem_subject":"human cell","subitem_subject_scheme":"Other"},{"subitem_subject":"human tissue","subitem_subject_scheme":"Other"},{"subitem_subject":"keloid","subitem_subject_scheme":"Other"},{"subitem_subject":"male","subitem_subject_scheme":"Other"},{"subitem_subject":"microarray analysis","subitem_subject_scheme":"Other"},{"subitem_subject":"pathogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"priority journal","subitem_subject_scheme":"Other"},{"subitem_subject":"protein expression","subitem_subject_scheme":"Other"},{"subitem_subject":"RNA binding","subitem_subject_scheme":"Other"},{"subitem_subject":"skin surgery","subitem_subject_scheme":"Other"},{"subitem_subject":"upregulation","subitem_subject_scheme":"Other"},{"subitem_subject":"Adolescent","subitem_subject_scheme":"Other"},{"subitem_subject":"Aged, 80 and over","subitem_subject_scheme":"Other"},{"subitem_subject":"Collagen Type I","subitem_subject_scheme":"Other"},{"subitem_subject":"Collagen Type III","subitem_subject_scheme":"Other"},{"subitem_subject":"CpG Islands","subitem_subject_scheme":"Other"},{"subitem_subject":"Dermis","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA Methylation","subitem_subject_scheme":"Other"},{"subitem_subject":"Down-Regulation","subitem_subject_scheme":"Other"},{"subitem_subject":"Female","subitem_subject_scheme":"Other"},{"subitem_subject":"Fibroblasts","subitem_subject_scheme":"Other"},{"subitem_subject":"Luciferases","subitem_subject_scheme":"Other"},{"subitem_subject":"Middle Aged","subitem_subject_scheme":"Other"},{"subitem_subject":"Primary Cell Culture","subitem_subject_scheme":"Other"},{"subitem_subject":"Promoter Regions","subitem_subject_scheme":"Other"},{"subitem_subject":"Genetic","subitem_subject_scheme":"Other"},{"subitem_subject":"Real-Time Polymerase Chain Reaction","subitem_subject_scheme":"Other"},{"subitem_subject":"Young Adult","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"miR-196a Downregulation Increases the Expression of Type I and III Collagens in Keloid Fibroblasts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"miR-196a Downregulation Increases the Expression of Type I and III Collagens in Keloid Fibroblasts"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-01-01"},"publish_date":"2013-01-01","publish_status":"0","recid":"10659","relation_version_is_last":true,"title":["miR-196a Downregulation Increases the Expression of Type I and III Collagens in Keloid Fibroblasts"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T01:25:21.180507+00:00"}