{"created":"2023-05-15T16:37:26.316350+00:00","id":10818,"links":{},"metadata":{"_buckets":{"deposit":"b7ddf9f9-41c8-4f25-aba7-2f692a8bf86d"},"_deposit":{"created_by":2,"id":"10818","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"10818"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00010818","sets":["8:9"]},"author_link":["42501","42503","42502","42506","42508","42504","42509","42507","42505"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"E1050","bibliographicPageStart":"E1043","bibliographicVolumeNumber":"97","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Endocrinology & Metabolism"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: Type 1 diabetes (T1D) iscommonlyassociated withautoimmunethyroid disease (AITD),and the occurrence of both T1D and AITD in a patient is defined as autoimmune polyglandular syndrome type 3 variant (APS3v). We aimed to clarify the differences in the clinical and genetic characteristics of APS3v patients and T1D patients without AITD [T1D/AITD(-)] in the Japanese population. Design/Patients: Our subjects were 54 APS3v patients and 143 T1D/AITD(-) patients who were consecutively diagnosed at Nagasaki University Hospital from 1983 to the present. Results: A remarkable female predominance, a slow and older age onset of T1D, and a higher prevalence of glutamic acid decarboxylase autoantibodies were observed in APS3v patients compared to T1D/AITD(-) patients. The older onset age of T1D in APS3v patients was associated with a higher proportion of slow-onset T1D. Among the two major susceptible human leukocyte antigen (HLA) class II haplotypes in Japanese T1D, DRB1*0405- DQB1*0401, but not DRB1*0901-DQB1*0303, was associated with APS3v patients. Furthermore, DRB1*0803-DQB1*0601 was not protective in patients with APS3v. The frequencies of the GG genotype in +49G>A and +6230G>A polymorphism in the CTLA4 gene were significantly higher in T1D/AITD(-) patients, but not in APS3v patients, compared to control subjects. Conclusions: In conclusion, we found notable differences in the clinical and genetic characteristics of APS3v patients and T1D/AITD(-) patients in the Japanese population, and the differences in the clinical characteristics between the two groups may reflect distinct genetic backgrounds including the HLA DRB1-DQB1 haplotypes and CTLA4 gene polymorphisms.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Clinical Endocrinology & Metabolism, 97(6), pp.E1043-E1050; 2012","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Endocrine Society"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1210/jc.2011-3109","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2012 by The Endocrine Society."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021972X","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Horie, Ichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawasaki, Eiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ando, Takao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kuwahara, Hironaga"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Abiru, Norio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Usa, Toshiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamasaki, Hironori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ejima, Eri"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakami, Atsushi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"JCEM97_1043.pdf","filesize":[{"value":"189.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JCEM97_1043.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/10818/files/JCEM97_1043.pdf"},"version_id":"a002b972-34b6-4346-93be-e8f9d0012757"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"autoantibody","subitem_subject_scheme":"Other"},{"subitem_subject":"cytotoxic T lymphocyte antigen 4","subitem_subject_scheme":"Other"},{"subitem_subject":"glutamate decarboxylase antibody","subitem_subject_scheme":"Other"},{"subitem_subject":"HLA DQB1 antigen","subitem_subject_scheme":"Other"},{"subitem_subject":"HLA DRB1 antigen","subitem_subject_scheme":"Other"},{"subitem_subject":"adult","subitem_subject_scheme":"Other"},{"subitem_subject":"article","subitem_subject_scheme":"Other"},{"subitem_subject":"autoimmune disease","subitem_subject_scheme":"Other"},{"subitem_subject":"autoimmune polygrandular syndrome type 3","subitem_subject_scheme":"Other"},{"subitem_subject":"autoimmune thyroiditis","subitem_subject_scheme":"Other"},{"subitem_subject":"clinical feature","subitem_subject_scheme":"Other"},{"subitem_subject":"controlled study","subitem_subject_scheme":"Other"},{"subitem_subject":"CTLA4 gene","subitem_subject_scheme":"Other"},{"subitem_subject":"disease association","subitem_subject_scheme":"Other"},{"subitem_subject":"female","subitem_subject_scheme":"Other"},{"subitem_subject":"gene","subitem_subject_scheme":"Other"},{"subitem_subject":"gene frequency","subitem_subject_scheme":"Other"},{"subitem_subject":"genetic analysis","subitem_subject_scheme":"Other"},{"subitem_subject":"genetic association","subitem_subject_scheme":"Other"},{"subitem_subject":"haplotype","subitem_subject_scheme":"Other"},{"subitem_subject":"human","subitem_subject_scheme":"Other"},{"subitem_subject":"insulin dependent diabetes mellitus","subitem_subject_scheme":"Other"},{"subitem_subject":"Japanese","subitem_subject_scheme":"Other"},{"subitem_subject":"major clinical study","subitem_subject_scheme":"Other"},{"subitem_subject":"male","subitem_subject_scheme":"Other"},{"subitem_subject":"onset age","subitem_subject_scheme":"Other"},{"subitem_subject":"priority journal","subitem_subject_scheme":"Other"},{"subitem_subject":"sex difference","subitem_subject_scheme":"Other"},{"subitem_subject":"single nucleotide polymorphism","subitem_subject_scheme":"Other"},{"subitem_subject":"Adolescent","subitem_subject_scheme":"Other"},{"subitem_subject":"Age of Onset","subitem_subject_scheme":"Other"},{"subitem_subject":"Asian Continental Ancestry Group","subitem_subject_scheme":"Other"},{"subitem_subject":"Autoantibodies","subitem_subject_scheme":"Other"},{"subitem_subject":"Child","subitem_subject_scheme":"Other"},{"subitem_subject":"Child, Preschool","subitem_subject_scheme":"Other"},{"subitem_subject":"Diabetes Mellitus, Type 1","subitem_subject_scheme":"Other"},{"subitem_subject":"Female","subitem_subject_scheme":"Other"},{"subitem_subject":"Haplotypes","subitem_subject_scheme":"Other"},{"subitem_subject":"HLA-DQ beta-Chains","subitem_subject_scheme":"Other"},{"subitem_subject":"HLA-DRB1 Chains","subitem_subject_scheme":"Other"},{"subitem_subject":"Humans","subitem_subject_scheme":"Other"},{"subitem_subject":"Islets of Langerhans","subitem_subject_scheme":"Other"},{"subitem_subject":"Japan","subitem_subject_scheme":"Other"},{"subitem_subject":"Middle Aged","subitem_subject_scheme":"Other"},{"subitem_subject":"Polyendocrinopathies","subitem_subject_scheme":"Other"},{"subitem_subject":"Autoimmune","subitem_subject_scheme":"Other"},{"subitem_subject":"Prevalence","subitem_subject_scheme":"Other"},{"subitem_subject":"Seroepidemiologic Studies","subitem_subject_scheme":"Other"},{"subitem_subject":"Sex Distribution","subitem_subject_scheme":"Other"},{"subitem_subject":"Thyroiditis","subitem_subject_scheme":"Other"},{"subitem_subject":"Autoimmune","subitem_subject_scheme":"Other"},{"subitem_subject":"Young Adult","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Clinical and genetic characteristics of autoimmune polyglandular syndrome type 3 variant in the Japanese population","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clinical and genetic characteristics of autoimmune polyglandular syndrome type 3 variant in the Japanese population"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-07-01"},"publish_date":"2013-07-01","publish_status":"0","recid":"10818","relation_version_is_last":true,"title":["Clinical and genetic characteristics of autoimmune polyglandular syndrome type 3 variant in the Japanese population"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T01:23:52.206246+00:00"}