{"created":"2023-05-15T16:30:05.229304+00:00","id":1086,"links":{},"metadata":{"_buckets":{"deposit":"f4a11fcd-e20f-499f-8177-aecdc7b05028"},"_deposit":{"created_by":2,"id":"1086","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"1086"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00001086","sets":["8:9"]},"author_link":["5205","5201","5206","5208","5197","5196","5203","5204","5202","5210","5198","5200","5199","5207","5209"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-02","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"41","bibliographicPageStart":"34","bibliographicVolumeNumber":"65","bibliographic_titles":[{"bibliographic_title":"Leukemia Research"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The myeloperoxidase (MPO)-positivity of blasts in bone marrow smears is an important marker for not only the diagnosis, but also the prognosis of acute myeloid leukemia (AML). To investigate the relationship between genetic alterations and MPO-positivity, we performed targeted sequencing for 51 genes and 10 chimeric gene transcripts in 164 newly diagnosed de novo AML patients; 107 and 57 patients were classified as AML with >50% MPO-positive blasts (MPO-high group) and ?50% MPO-positive blasts, (MPO-low group), respectively. The univariate analysis revealed that RUNX1-RUNX1T1 (P < 0.001), the KIT mutation (P < 0.001), and CEBPA double mutation (P = 0.001) were more likely to be found in the MPO-high group, while the DNMT3A mutation (P = 0.001), FLT3 tyrosine kinase domain mutation (P = 0.004), and TP53 mutation (P = 0.020) were more likely to be present in the MPO-low group. Mutations in genes related to DNA hypermethylation signatures (IDH1, IDH2, TET2, and WT1 genes) were more frequent in the MPO-high group (P = 0.001) when patients with fusion genes of core-binding factors were excluded from the analysis. Our results suggest that MPO-positivity of blasts was related with the distinct gene mutation patterns among de novo AML patients.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Leukemia Research, 65, pp.34-41; 2018","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Ltd."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.leukres.2017.12.006","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2017 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"01452126","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kamijo, Rena"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Itonaga, Hidehiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kihara, Rika"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagata, Yasunobu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hata, Tomoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Asou, Norio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohtake, Shigeki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiraishi, Yuichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chiba, Kenichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Hiroko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyano, Satoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogawa, Seishi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Naoe, Tomoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kiyoi, Hitoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyazaki, Yasushi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"LeukRes65_34.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"LeukRes65_34.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/1086/files/LeukRes65_34.pdf"},"version_id":"1208e163-bb64-4e4c-9729-007ff00bc0a8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Acute myeloid leukemia","subitem_subject_scheme":"Other"},{"subitem_subject":"Gene mutation","subitem_subject_scheme":"Other"},{"subitem_subject":"Myeloperoxidase","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Distinct gene alterations with a high percentage of myeloperoxidase-positive leukemic blasts in  de novo  acute myeloid leukemia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Distinct gene alterations with a high percentage of myeloperoxidase-positive leukemic blasts in  de novo  acute myeloid leukemia"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-03-01"},"publish_date":"2019-03-01","publish_status":"0","recid":"1086","relation_version_is_last":true,"title":["Distinct gene alterations with a high percentage of myeloperoxidase-positive leukemic blasts in  de novo  acute myeloid leukemia"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:07:53.708708+00:00"}