{"created":"2023-05-15T16:37:32.721732+00:00","id":10933,"links":{},"metadata":{"_buckets":{"deposit":"309a3aa0-8906-472c-9a20-a8b78302c4db"},"_deposit":{"created_by":2,"id":"10933","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"10933"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00010933","sets":["8:9"]},"author_link":["42841","42835","42840","42837","42838","42839","42836"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"97","bibliographicPageStart":"92","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"Shock"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Systemic administration of α2-adrenergic agonists has been shown to protect ischemic myocardium, but the direct effects on ischemia-reperfused myocardium have not yet been clarified. This study was carried out to determine the effects of intracoronary dexmedetomidine (DEX) on the myocardial ischemia-reperfusion injury in anesthetized pigs. In open-chest pigs, the left anterior descending coronary artery was perfused through an extracorporeal circuit from the carotid artery. They received intracoronary infusion of DEX at a rate of 1 ng • mL -1 (group LD, n = 9), 10 ng • mL -1 (group MD, n = 9), or 100 ng • mL -1 (group HD, n = 9) of coronary blood flow or vehicle (group C, n = 12) for 30 min before ischemia. Myocardial stunning was produced by 12-min ischemia of the perfused area of left anterior descending coronary artery and 90-min reperfusion. The effect on reperfusion-induced arrhythmias was evaluated using the incidence of ventricular tachycardia or fibrillation after reperfusion. Regional myocardial contractility was evaluated with segment shortening (%SS). Dexmedetomidine significantly reduced the incidence of reperfusion-induced ventricular arrhythmias. Dexmedetomidine significantly improved the recovery of percentage segment shortening at 90 min after reperfusion (32.6% ± 3.1% in group C, 58.2% ± 2.1% in group LD, 61.1% ± 1.8% in group MD, and 72.0% ± 2.0% in group HD). Dexmedetomidine suppressed the increase in plasma norepinephrine concentration after reperfusion. The results indicate that DEX would exert the protective effect against ischemia-reperfusion injury by the direct action on the myocardium, which is not mediated through the central nervous system.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Shock, 38(1), pp.92-97; 2012","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Lippincott Williams and Wilkins"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1097/SHK.0b013e318254d3fb","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2012 by the Shock Society."},{"subitem_rights":"This is a non-final version of an article published in final form in Shock, 38(1), pp.92-97; 2012\"."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"10732322","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshitomi, Osamu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Cho, Sungsam"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hara, Tetsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibata, Itsuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maekawa, Takuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ureshino, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sumikawa, Koji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"Shock38_92.pdf","filesize":[{"value":"165.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Shock38_92.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/10933/files/Shock38_92.pdf"},"version_id":"aef49f21-7247-4473-8405-16129f9976e2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"dexmedetomidine","subitem_subject_scheme":"Other"},{"subitem_subject":"myocardial stunning","subitem_subject_scheme":"Other"},{"subitem_subject":"norepinephrine","subitem_subject_scheme":"Other"},{"subitem_subject":"α2-adrenergic agonist","subitem_subject_scheme":"Other"},{"subitem_subject":"myocardial ischemia","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Direct protective effects of dexmedetomidine against myocardial ischemia-reperfusion injury in anesthetized pigs","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Direct protective effects of dexmedetomidine against myocardial ischemia-reperfusion injury in anesthetized pigs"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-08-01"},"publish_date":"2013-08-01","publish_status":"0","recid":"10933","relation_version_is_last":true,"title":["Direct protective effects of dexmedetomidine against myocardial ischemia-reperfusion injury in anesthetized pigs"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T01:22:42.972121+00:00"}