@article{oai:nagasaki-u.repo.nii.ac.jp:00010943,
 author = {Ozeki, Ayumi and Suzuki, Keiji and Suzuki, Masatoshi and Ozawa, Hiroki and Yamashita, Shunichi},
 issue = {5},
 journal = {NeuroReport},
 month = {Mar},
 note = {Neural stem cells (NSCs) are highly susceptible to DNA double-strand breaks; however, little is known about the effects of radiation in cells surviving radiation. Although the nestin-positive NSCs predominantly became glial fibrillary acidic protein (GFAP)-positive in differentiation-permissive medium, little or no cells were GFAP positive in proliferation-permissive medium. We found that more than half of the cells surviving X-rays became GFAP positive in proliferation-permissive medium. Moreover, localized irradiation stimulated differentiation of cells outside the irradiated area. These results indicate for the first time that ionizing radiation is able to stimulate astrocyte-specific differentiation of surviving NSCs, whose process is mediated both by the direct activation of nuclear factor-jB and by the indirect bystander effect induced by X-irradiation., NeuroReport, 23(5), pp.290-293; 2012},
 pages = {290--293},
 title = {Acceleration of astrocytic differentiation in neural stem cells surviving X-irradiation},
 volume = {23},
 year = {2012}
}