{"created":"2023-05-15T16:30:07.020048+00:00","id":1127,"links":{},"metadata":{"_buckets":{"deposit":"65d36d3b-7f65-4bf1-b99f-c413255eb820"},"_deposit":{"created_by":2,"id":"1127","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"1127"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00001127","sets":["10:11"]},"author_link":["5351","5350","5356","5357","5355","5348","5358","5353","5352","5349","5354"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"860","bibliographicPageStart":"853","bibliographicVolumeNumber":"138","bibliographic_titles":[{"bibliographic_title":"YAKUGAKU ZASSHI"},{"bibliographic_title":"薬学雑誌","bibliographic_titleLang":"en"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The physicochemical compatibility between injections of different agents is very important. An injection of the antibiotic vancomycin (VCM) is acidic and its standard pH range is 2.5-4.5. In clinical treatments, VCM injections are often used with LasixR (furosemide) injections. The LasixR injection is alkaline and its standard pH range is 8.6-9.6. Therefore, mixing VCM injections with LasixR injections may cause compatibility problems. We evaluated the effect of pH on the compatibility between VCM (original and two generic) and LasixR injections. Compatibility was not observed in non-pH-adjusted VCM with LasixR injections, but white crystals appeared when VCM injections adjusted to pH 2.5 experimentally were mixed with a LasixR injection, suggesting that the acidic condition of VCM injections cause compatibility. However, the residual rates of VCM did not change after 24 h in all mixtures. We analyzed the crystals by mass spectrometry and 1H-NMR, and identified them to comprise furosemide.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Yakugaku Zasshi, 138(6), pp.853-860; 2018","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Pharmaceutical Society of Japan"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/yakushi.18-00004","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2018 The Pharmaceutical Society of Japan."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00316903","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13475231","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"日本薬学会"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Munakata, Chie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fuchigami, Yuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Makizoe, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miura, Yusuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamaoka, Mariko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasahara, Satomi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hata, Katsutomo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tachiki, Hidehisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Hitoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hagimori, Masayori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakami, Shigeru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"Yakugaku138_853.pdf","filesize":[{"value":"434.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Yakugaku138_853.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/1127/files/Yakugaku138_853.pdf"},"version_id":"d798be20-9780-4ad6-ae96-dc077ead0f7e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"compatibility","subitem_subject_scheme":"Other"},{"subitem_subject":"furosemide","subitem_subject_scheme":"Other"},{"subitem_subject":"generic drug","subitem_subject_scheme":"Other"},{"subitem_subject":"vancomycin","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of pH and Additives on the Compatibility between Vancomycin and Furosemide Injections","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of pH and Additives on the Compatibility between Vancomycin and Furosemide Injections"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-12"},"publish_date":"2018-07-12","publish_status":"0","recid":"1127","relation_version_is_last":true,"title":["Effect of pH and Additives on the Compatibility between Vancomycin and Furosemide Injections"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:07:27.733742+00:00"}